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Effects of the ketogenic diet in the treatment of gliomas: A systematic review

2022Journal article Open access
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dc.contributor.authorSargaço, Beatriz
dc.contributor.authorOliveira, Patrícia Almeida
dc.contributor.authorAntunes, Maria Da Luz
dc.contributor.authorMoreira, Ana Catarina
dc.date.accessioned2022-03-18T19:49:35Z
dc.date.available2022-03-18T19:49:35Z
dc.date.issued2022
dc.description.abstract: The ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic, normoproteic, and hypoglucidic. This diet simulates biochemical changes related to fasting periods to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in investigations and nutritional strategies, such as KD, to modulate the glycemic response as a treatment. This systematic review followed the PRISMA recommendations and was published in PROSPERO, with the identification CRD42021264173. The databases used were EMBASE, PubMed/Medline, Scopus, and Web of Science, and the studies were analyzed using the web-based application Rayyan. To analyze the risk of bias, Cochrane RevMan 5 software was used. For the analysis and treatment of statistical data, Microsoft®Excel®was used. A total of nine original articles were included. Data on survival, symptomology, and quality of life were collected. Mean overall survival was 15.9 months. Constipation and fatigue were the most reported symptoms. In 44.4% of the studies, an improvement in the quality of life was found. The KD is supported by most published studies as an effective therapy in the treatment of malignant gliomas due to its positive effects on patient survival. It was not possible to conclude the effectiveness of KD on quality of life.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSargaço, B., Oliveira, P. A., Antunes, M. L., & Moreira, A. C. (2022). Effects of the ketogenic diet in the treatment of gliomas: A systematic review. Nutrients, 14(5) https://doi.org/10.3390/nu14051007pt_PT
dc.identifier.doi10.3390/nu14051007pt_PT
dc.identifier.issn20726643
dc.identifier.urihttp://hdl.handle.net/10400.12/8614
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI Multidisciplinary Digital Publishing Institutept_PT
dc.relationHealth and Technology Research Center
dc.relationHealth and Technology Research Center
dc.subjectKetogenic dietpt_PT
dc.subjectGliomapt_PT
dc.subjectGlioblastomapt_PT
dc.subjectSurvivalpt_PT
dc.titleEffects of the ketogenic diet in the treatment of gliomas: A systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth and Technology Research Center
oaire.awardTitleHealth and Technology Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05608%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05608%2F2020/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage17pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSargaço
person.familyNameAntunes
person.givenNameBeatriz
person.givenNameMaria da Luz
person.identifier.orcid0000-0003-1551-9529
person.identifier.orcid0000-0001-9360-5284
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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