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Publication
Effects of the ketogenic diet in the treatment of gliomas: A systematic review
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Advisor(s)
Abstract(s)
: The ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic,
normoproteic, and hypoglucidic. This diet simulates biochemical changes related to fasting periods
to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in
investigations and nutritional strategies, such as KD, to modulate the glycemic response as a treatment.
This systematic review followed the PRISMA recommendations and was published in PROSPERO,
with the identification CRD42021264173. The databases used were EMBASE, PubMed/Medline,
Scopus, and Web of Science, and the studies were analyzed using the web-based application Rayyan.
To analyze the risk of bias, Cochrane RevMan 5 software was used. For the analysis and treatment of
statistical data, Microsoft®Excel®was used. A total of nine original articles were included. Data on
survival, symptomology, and quality of life were collected. Mean overall survival was 15.9 months.
Constipation and fatigue were the most reported symptoms. In 44.4% of the studies, an improvement
in the quality of life was found. The KD is supported by most published studies as an effective
therapy in the treatment of malignant gliomas due to its positive effects on patient survival. It was
not possible to conclude the effectiveness of KD on quality of life.
Description
Keywords
Ketogenic diet Glioma Glioblastoma Survival
Citation
Sargaço, B., Oliveira, P. A., Antunes, M. L., & Moreira, A. C. (2022). Effects of the ketogenic diet in the treatment of gliomas: A systematic review. Nutrients, 14(5) https://doi.org/10.3390/nu14051007
Publisher
MDPI Multidisciplinary Digital Publishing Institute