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Dietary acid load and relationship with albuminuria and glomerular filtration rate in iIndividuals with chronic kidney Disease at Predialysis State
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Authors
Advisor(s)
Abstract(s)
: The Western diet, characterized by excessive consumption of animal protein and reduced
intake of vegetables and fruits, is also rich in sulfur, chlorine, and organic acids, which are the main
sources of dietary acid load. A relationship between dietary acid load, renal function, and progression
of chronic kidney disease has been demonstrated. Dietary modifications seem to contribute to a
reduction in dietary acid load, and are associated with improved outcomes in individuals with
chronic kidney disease (CKD). The aim of this paper was to review the existing evidence concerning
the association between dietary acid load and renal function in nondialyzed individuals with CKD. A
systematic review was conducted by gathering articles in electronic databases (MEDLINE/PubMed,
Scopus, and Web of Science) from January 2018 to May 2021. Dietary acid load and GFR and/or
albuminuria were analyzed. A total of 1078 articles were extracted, of which 5 met the inclusion
criteria. Only one study found no statistically significant associations between the study variables.
The remaining showed a negative association between dietary acid load and renal function. This
systematic review confirmed the existence of an association between dietary acid load and renal
function, with a high dietary acid load contributing to a decreased renal function.
Description
Keywords
Chronic renal insufficiency Acidosis Diet
Citation
Silva, L; Moço, S. A., Antunes, M. L., Ferreira, A. S. &, Moreira, A. C.(2021). Dietary acid load and relationship with albuminuria and glomerular filtration rate in iIndividuals with chronic kidney Disease at Predialysis State. Nutrients, 14(1), 170-181
Publisher
MDPI Multidisciplinary Digital Publishing Institute