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Forebrain transcriptional response to transient changes in circulating androgens in a cichlid fish

2020Journal article Open access
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dc.contributor.authorFélix, Ana Sofia
dc.contributor.authorD. Cardoso, Sara
dc.contributor.authorRoleira, António
dc.contributor.authorOliveira, Rui Filipe
dc.date.accessioned2020-06-18T16:28:12Z
dc.date.available2020-06-18T16:28:12Z
dc.date.issued2020
dc.description.abstractIt has been hypothesized that androgens respond to the social interactions as a way to adjust the behavior of individuals to the challenges of the social environment in an adaptive manner. Therefore, it is expected that transient changes in circulating androgen levels within physiological scope should impact the state of the brain network that regulates social behavior, which should translate into adaptive behavioral changes. Here, we examined the effect that a transient peak in androgen circulating levels, which mimics socially driven changes in androgen levels, has on the forebrain state, which harbors most nuclei of the social decision-making network. For this purpose, we successfully induced transient changes in circulating androgen levels in an African cichlid fish (Mozambique tilapia, Oreochromis mossambicus) commonly used as a model in behavioral neuroendocrinology by injecting 11-ketotestosterone or testosterone, and compared the forebrain transcriptome of these individuals to control fish injected with vehicle. Forebrain samples were collected 30 min and 60 min after injection and analyzed using RNAseq. Our results showed that a transient peak in 11-ketotestosterone drives more accentuated changes in forebrain transcriptome than testosterone, and that transcriptomic impact was greater at the 30 min than at the 60 min post-androgen administration. Several genes involved in the regulation of translation, steroid metabolism, ion channel membrane receptors, and genes involved in epigenetic mechanisms were differentially expressed after 11-ketotestosterone or testosterone injection. In summary, this study identified specific candidate genes that may regulate socially driven changes in behavioral flexibility mediated by androgens.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationG3: Genes, Genomes, Genetics, 10(6), 1971-1982pt_PT
dc.identifier.doi10.1534/g3.119.400947pt_PT
dc.identifier.issn14616734
dc.identifier.urihttp://hdl.handle.net/10400.12/7641
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherGenetics Society of Americapt_PT
dc.relationMolecular mechanisms and evolutionary implications of social plasticity
dc.relationUnraveling the mechanisms underlying the androgen response to social interactions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAndrogenspt_PT
dc.subjectChallengept_PT
dc.subjectHypothesispt_PT
dc.subjectTranscriptomept_PT
dc.subjectSociogenomicspt_PT
dc.subjectBrainpt_PT
dc.titleForebrain transcriptional response to transient changes in circulating androgens in a cichlid fishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular mechanisms and evolutionary implications of social plasticity
oaire.awardTitleUnraveling the mechanisms underlying the androgen response to social interactions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXCL%2FBIA-ANM%2F0549%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F102892%2F2014/PT
oaire.citation.conferencePlaceUnited Statespt_PT
oaire.citation.endPage1982pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1971pt_PT
oaire.citation.titleAttachment and Human Developmentpt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameFélix
person.familyNameCardoso
person.familyNameOliveira
person.givenNameAna Sofia
person.givenNameSara
person.givenNameRui
person.identifier760975
person.identifier301219
person.identifier.ciencia-idD318-BC7B-61D2
person.identifier.ciencia-id991E-446C-750C
person.identifier.ciencia-id611C-50AD-6CE7
person.identifier.orcid0000-0002-3104-2495
person.identifier.orcid0000-0002-1006-2323
person.identifier.orcid0000-0003-1528-618X
person.identifier.ridH-1372-2012
person.identifier.ridA-3581-2013
person.identifier.scopus-author-id55882062100
person.identifier.scopus-author-id55889189700
person.identifier.scopus-author-id35561080400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication00d0d929-5def-48bc-9b33-2b71381f2214
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