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Different MMSE domains are associated to cognitive decline and education

2022Journal article Open access
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dc.contributor.authorCardoso, Sandra
dc.contributor.authorBarros, Ricardo
dc.contributor.authorMaroco, J. P.
dc.contributor.authorMendonça, Alexandre de
dc.contributor.authorGuerreiro, Manuela
dc.date.accessioned2022-04-14T14:18:38Z
dc.date.available2022-04-14T14:18:38Z
dc.date.issued2022
dc.description.abstractThe Mini-Mental State Examination (MMSE) is a long-established test to screen for dementia, estimate the severity and monitor the progression of cognitive impairment. The MMSE total score is dependent upon demographic factors, particularly education, but little is known about how education influences the 6 distinct MMSE cognitive domains. The present study aims to understand how the performances in the MMSE cognitive domains reflect clinical diagnosis and educational level. The study recruited 1043 participants, comprising 388 healthy controls, 360 patients with Mild Cognitive Impairment (MCI) and 295 patients with dementia. The association of the MMSE cognitive domains scores with clinical diagnosis (healthy, MCI, dementia) and educational level (primary education, middle school, high school and university/college) was analyzed with a multivariate ordinal regression model. The scores in all MMSE domains were generally higher in healthy controls as compared to patients with MCI, and higher in these as compared to patients with dementia. The MMSE domain Constructional ability was associated to the education level, the domains Orientation, Recall and Language were associated to diagnosis, Attention and calculation was associated to both education level and diagnosis, and Registration was not associated to either education or diagnosis. In conclusion, impairment in specific MMSE domains pinpoints cognitive decline, probably indicating brain areas affected by neurodegeneration, and impairment in others reflects lower education levels and the lack of acquisition of relevant schooling abilities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCardoso, S., Barros, R., Marôco, J., de Mendonça, A., & Guerreiro, M. (2022). Different MMSE domains are associated to cognitive decline and education. Applied Neuropsychology: Adult, 1–7. https://doi.org/10.1080/23279095.2022.2041018pt_PT
dc.identifier.doi10.1080/23279095.2022.2041018pt_PT
dc.identifier.issn2327-9095
dc.identifier.urihttp://hdl.handle.net/10400.12/8640
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoutledgept_PT
dc.subjectCognitive declinept_PT
dc.subjectDementiapt_PT
dc.subjectDomainspt_PT
dc.subjectEducationpt_PT
dc.subjectMiniMental state examinationpt_PT
dc.subjectMMSEpt_PT
dc.subjectMild cognitive impairmentpt_PT
dc.titleDifferent MMSE domains are associated to cognitive decline and educationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Statespt_PT
oaire.citation.endPage7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleApplied Neuropsychology: Adultpt_PT
person.familyNameCardoso
person.familyNamePaulo Marôco Domingos
person.familyNameGuerreiro
person.givenNameSandra
person.givenNameJoão
person.givenNameManuela
person.identifierD-4339-2015
person.identifier.ciencia-id021F-EE93-4109
person.identifier.ciencia-idD81B-BE2D-9B43
person.identifier.ciencia-id0616-9DC2-CCD3
person.identifier.orcid0000-0001-9214-5378
person.identifier.orcid0000-0002-6398-9712
person.identifier.scopus-author-id6602157617
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd4d5385e-fce6-4274-bfd2-2385050f2c55
relation.isAuthorOfPublication14869d29-f5c4-4476-a172-ad161c7400e6
relation.isAuthorOfPublicationaaabc76c-3064-45af-9332-897322357a83
relation.isAuthorOfPublication.latestForDiscovery14869d29-f5c4-4476-a172-ad161c7400e6

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