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Advisor(s)
Abstract(s)
Objective: Patients with amnestic Mild Cognitive Impairment (aMCI), usually
considered an early stage of Alzheimer's disease, have deficits not only in retrospective
memory (RM), that is, recalling of past events, words or people, but also on
prospective memory (PM), the cognitive ability of remembering to execute delayed
intentions in the future. This study investigated whether patients with aMCI refer
more PM complaints as compared with RM complaints, and whether this might
depend upon short‐term vs long‐term items or time‐based vs event‐based tasks.
Methods: Patients with aMCI (n = 178) and healthy controls (n = 160) underwent
the Prospective and Retrospective Memory Questionnaire (PRMQ), a 16‐item instrument
to appraise differences between PM and RM complaints, as well as a general
mental state examination, a subjective memory complaints questionnaire, objective
memory tests, and assessment of depressive symptoms and activities of daily living.
Results: Patients with aMCI reported more memory complaints evaluated with the
PRMQ (total score = 44.3 ± 10.8) as compared with controls (36.7 ± 9.8, P < 0.001).
Using a mixed effect repeated‐measures analysis of covariance (ANCOVA) showed
that participants generally referred more retrospective than prospective memory
complaints. Patients with aMCI had significantly more complaints on short‐term memory
as compared with long‐term memory, and more complaints in time‐based (autoinitiated)
as compared with event‐based tasks, than healthy controls.
Conclusion: Patients with aMCI reported significantly more difficulties on shortterm
memory, presumably reflecting internal temporal lobe pathology typical of
Alzheimer's disease, and more complaints on time‐based tasks, which are cognitively
very demanding, but did not seem particularly troubled regarding prospective
memory.
Description
Keywords
Event based Long‐term memory Mild cognitive impairment Prospective memory Retrospective memory Short‐term memory Time based
Citation
International Journal of Geriatric Psychiatry, 1-8. Doi: 10.1002/gps.4886
Publisher
Wiley