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Publication
A systematic review and meta-analysis on the role of psychological support in treatments with psilocybin
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Authors
Advisor(s)
Abstract(s)
Introdução: Após o ressurgimento da investigação da psilocibina, os ensaios clínicos têm
apresentado resultados promissores relativamente ao efeito terapêutico deste composto nas
perturbações relacionadas com a depressão. Embora tenha sido dada uma atenção considerável
ao set e setting, nenhum estudo testou empiricamente o papel do apoio psicológico no aumento
dos resultados clínicos positivos. Objetivo: O propósito deste estudo é realizar uma revisão
sistemática e uma meta-análise para compreender se a psilocibina com intervenção psicológica
é clinicamente eficaz e também avaliar como as variáveis da intervenção psicológica
influenciam o efeito. Métodos: A estratégia de pesquisa e seleção foi concebida de acordo com
as normas PRISMA. Foram utilizadas seis bases de dados e a lista final de artigos foi submetida
a um processo de seleção independente do título, depois do resumo e, por fim, do texto integral.
Foi concebido um modelo de extração de dados. A subsequente extração foi realizada por dois
avaliadores independentes. Resultados: A revisão sistemática produziu um total de oito estudos
no grupo dos estudos controlados randomizados e 10 estudos no grupo de ensaios clínicos.
Ambas as meta-análises indicaram tamanhos de efeito significativos (p<0.001) e considerado
grande. Para testar possíveis moderadores, foram efetuadas meta-regressões, mas não se
obtiveram resultados significativos. Foram também efetuadas análises de subgrupos para
explorar potenciais fontes de modificação do efeito. Discussão: Os tratamentos com psilocibina
com apoio psicológico são clinicamente eficazes no tratamento de perturbações relacionadas
com a depressão. O número de estudos foi insuficiente para fornecer resultados conclusivos
sobre as variáveis da intervenção psicológica.
ABSTRACT: Background: After the resurgence of psilocybin research, clinical trials have reported promising results regarding the therapeutic effect this compound has in depressive-related disorders. Although a considerable amount of attention has been given to the set and setting, no study has tested empirically if psychological support augments clinical results. Objective: The aim of this study is to conduct a systematic review and meta-analysis to understand if psilocybin with psychological intervention is clinically effective and to assess how variables within psychological intervention influence the effect. Methods: The search and selection strategy were designed following the PRISMA guidelines. Six different electronic library databases were searched and the final list of articles resulted from a process of independent review of title, then abstract and ultimately full text. A database template was designed and subsequent data extraction was conducted by two independent raters. Results: The systematic review yielded a total of eight studies in the randomized controlled trial group and 10 studies in the clinical trial group. Both meta-analyses indicated significant (p<0.001) and large effect sizes. To test for possible moderators, meta-regressions were performed but there were no significant results in both groups. Subgroup analyses were also conducted to explore potential sources of modification of treatment effect according to different subgroups. Discussion: Psilocybin treatments with psychological support are clinically effective in treating depression-related disorders. Overall, the number of studies was insufficient to provide conclusive findings on psychological intervention variables. Limitations and future research are discussed.
ABSTRACT: Background: After the resurgence of psilocybin research, clinical trials have reported promising results regarding the therapeutic effect this compound has in depressive-related disorders. Although a considerable amount of attention has been given to the set and setting, no study has tested empirically if psychological support augments clinical results. Objective: The aim of this study is to conduct a systematic review and meta-analysis to understand if psilocybin with psychological intervention is clinically effective and to assess how variables within psychological intervention influence the effect. Methods: The search and selection strategy were designed following the PRISMA guidelines. Six different electronic library databases were searched and the final list of articles resulted from a process of independent review of title, then abstract and ultimately full text. A database template was designed and subsequent data extraction was conducted by two independent raters. Results: The systematic review yielded a total of eight studies in the randomized controlled trial group and 10 studies in the clinical trial group. Both meta-analyses indicated significant (p<0.001) and large effect sizes. To test for possible moderators, meta-regressions were performed but there were no significant results in both groups. Subgroup analyses were also conducted to explore potential sources of modification of treatment effect according to different subgroups. Discussion: Psilocybin treatments with psychological support are clinically effective in treating depression-related disorders. Overall, the number of studies was insufficient to provide conclusive findings on psychological intervention variables. Limitations and future research are discussed.
Description
Dissertação de Mestrado realizada sob
a orientação da Professora Doutora
Carolina Seybert, apresentada no Ispa
– Instituto Universitário para obtenção
de grau de Mestre na especialidade de
Psicologia Clínica.
Keywords
Psicadélicos Revisão sistemática Meta-análise Apoio psicológico Psilocibina psychedelics Systematic review Meta-analysis Psychological intervention Psilocybin