The relationship between fatigue, pruritus, and thirst distress with quality of life among patients receiving hemodialysis: a mediator model to test concept of treatment adherence

Sharif-Nia, Hamid; Maroco, J. P.; Sivarajan Froelicher, Erika; Barzegari, Saeed; Sadeghi, Niloofar; Fatehi, Reza

http://hdl.handle.net/10400.12/9773

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Authors

Sharif-Nia, Hamid

Maroco, J. P.

Sivarajan Froelicher, Erika

Barzegari, Saeed

Sadeghi, Niloofar

Fatehi, Reza

Abstract(s)

Hemodialysis is a conservative treatment for end-stage renal disease. It has various complications which negatively afect quality of life (QOL). This study aimed to examine the relationship between fatigue, pruritus, and thirst distress (TD) with QOL of patients receiving hemodialysis, while also considering the mediating role of treatment adherence (TA). This cross-sectional study was carried out in 2023 on 411 patients receiving hemodialysis. Participants were consecutively recruited from several dialysis centers in Iran. Data were collected using a demographic information form, the Fatigue Assessment Scale, the Thirst Distress Scale, the Pruritus Severity Scale, the 12-Item Short Form Health Survey, and the modifed version of the Greek Simplifed Medication Adherence Questionnaire for Hemodialysis Patients. Covariance-based structural equation modeling was used for data analysis. The structural model and hypothesis testing results showed that all hypotheses were supported in this study. QOL had a signifcant inverse association with fatigue, pruritus, and TD and a signifcant positive association with TA. TA partially mediated the association of QOL with fatigue, pruritus, and TD, denoting that it helped counteract the negative association of these complications on QOL. This model explained 68.5% of the total variance of QOL. Fatigue, pruritus, and TD have a negative association with QOL among patients receiving hemodialysis, while TA reduces these negative associations. Therefore, TA is greatly important to manage the associations of these complications and improve patient outcomes. Healthcare providers need to assign high priority to TA improvement among these patients to reduce their fatigue, pruritus, and TD and improve their QOL. Further studies are necessary to determine the most efective strategies for improving TA and reducing the burden of complications in this patient population.

Keywords

Fatigue Hemodialysis Pruritus Quality of life Tirst distress Treatment adherence

URI

http://hdl.handle.net/10400.12/9773

Citation

Sharif-Nia, H., Marôco, J., Froelicher, E. S., Barzegari, S., Sadeghi, N., & Fatehi, R. (2024). The relationship between fatigue, pruritus, and thirst distress with quality of life among patients receiving hemodialysis: a mediator model to test concept of treatment adherence. Scientific Reports, 1–12. https://doi.org/10.1038/s41598-024-60679-2