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The update of semantic memories in amnestic mild cognitive impairment

2021-04Journal article Open access
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dc.contributor.authorMendonça, Alexandre De
dc.contributor.authorCardoso, Sandra
dc.contributor.authorMarôco, J. P.
dc.contributor.authorGuerreiro, Manuela
dc.contributor.authorCarmo, Joana C
dc.date.accessioned2021-05-11T00:00:51Z
dc.date.available2021-05-11T00:00:51Z
dc.date.issued2021-04
dc.description.abstractIt is still controversial to what extent neocortical consolidated memories are susceptible of change by processes of reconsolidation and transformation throughout experience, and whether the medial temporal lobes are necessary for this update of semantic consolidated memories, as they are for episodic remembering. We hypothesize that patients with amnestic mild cognitive impairment (aMCI) who have deficits in episodic memory may also have difficulties in updating information on added new features of objects. Sixteen participants with aMCI and 20 healthy control participants performed a semantic word-to-picture task, in which they were asked to identify as belonging to a given semantic category NEW objects, that have incorporated novel features, as well as OLD items, semantically and visually SIMILAR items and UNRELATED items. Patients with aMCI made a greater percentage of errors than healthy controls. Participants globally made greater percentages of errors in difficult types of items, namely NEW and SIMILAR, as compared to easier ones, OLD and UNRELATED. Importantly, an item by diagnostic group interaction effect was observed, and post hoc analysis showed that patients with aMCI made a higher percentage of errors than controls in NEW items only. In conclusion, patients with aMCI had a particular difficulty in identifying the NEW items of the word-to-picture task as compared to the control participants, supporting the concept of a flexible and dynamic conceptual knowledge system, involving the update of semantic memories and the integration of new attributes in a constant transformation process, which is impaired in these patients.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMendonça, Alexandre de, Cardoso, S., Maroco, J., Guerreiro, M. & Carmo, Joana C. (2021).The update of semantic memories in amnestic mild cognitive impairment. Journal of Neuropsychology, 15(1), 27-40. https://doi.org/10.1016/j.ecoinf.2021.101281pt_PT
dc.identifier.doi10.1111/jnp.12217pt_PT
dc.identifier.issn17486653
dc.identifier.urihttp://hdl.handle.net/10400.12/8122
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-Blackwellpt_PT
dc.relationDL57/2016/CP1439/CT02pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleThe update of semantic memories in amnestic mild cognitive impairmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Statespt_PT
oaire.citation.endPage40pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage27pt_PT
oaire.citation.titleJournal of Neuropsychologypt_PT
oaire.citation.volume15pt_PT
person.familyNamede Mendonça
person.familyNameCardoso
person.familyNamePaulo Marôco Domingos
person.familyNameGuerreiro
person.givenNameAlexandre
person.givenNameSandra
person.givenNameJoão
person.givenNameManuela
person.identifierD-4339-2015
person.identifier.ciencia-id1615-41B4-0848
person.identifier.ciencia-id021F-EE93-4109
person.identifier.ciencia-idD81B-BE2D-9B43
person.identifier.ciencia-id0616-9DC2-CCD3
person.identifier.orcid0000-0002-0488-1453
person.identifier.orcid0000-0001-9214-5378
person.identifier.orcid0000-0002-6398-9712
person.identifier.scopus-author-id7003320823
person.identifier.scopus-author-id6602157617
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationd4d5385e-fce6-4274-bfd2-2385050f2c55
relation.isAuthorOfPublication14869d29-f5c4-4476-a172-ad161c7400e6
relation.isAuthorOfPublicationaaabc76c-3064-45af-9332-897322357a83
relation.isAuthorOfPublication.latestForDiscoveryd4d5385e-fce6-4274-bfd2-2385050f2c55

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