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- Adherence to phosphodiesterase type 5 Inhibitors in the treatment of frectile dysfunction in long-term users: How Do Men Use the Inhibitors?Publication . Carvalheira, Ana Alexandra; Forjaz, Vera; Pereira, Nuno MonteiroThe high effectiveness of phosphodiesterase type 5 inhibitors (PDE5-i) in the treatment of erectile dysfunction (ED) has been demonstrated. However, previous research shows that PDE5-i treatments have high discontinuation rates.