Browsing by Author "Martins, Jorge S."
Now showing 1 - 3 of 3
Results Per Page
Sort Options
- Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivationPublication . Seo, Dongju; Martins, Jorge S.; Sinha, RajitaHigh stress is a key risk factor for alcohol use disorder (AUD) and often accompanied by physiological dysregulation including autonomic nervous system (ANS) disruptions. However, neural mechanisms underlying drinking behaviors associated with stress and ANS disruptions remain unclear. The current study aims to understand neural correlates of stress, ANS disruptions, and subsequent alcohol intake in social drinkers with risky drinking. Using functional magnetic resonance imaging (fMRI), we investigated brain and heart rate (HR) autonomic responses during brief exposure to stress, alcohol, and neutral cues utilizing a well-validated, individualized imagery paradigm in 48 social drinkers of which 26 reported high-risk drinking (HD) while 22 reported low-risk drinking (LD) patterns. Results indicated that HD individuals showed stress and ANS disruptions with increased basal HR, stress-induced craving, and decreased brain response to stress exposure in frontal-striatal regions including the ventromedial prefrontal cortex (VmPFC), anterior cingulate cortex, striatum, insula, and temporal gyrus. Furthermore, whole-brain correlation analysis indicated that greater basal HR was associated with hypoactive VmPFC, but hyperactive medulla oblongata (MOb) responses during stress, with an inverse association between activity in the VmPFC and Mob (whole-brain corrected (WBC), p < 0.05). Functional connectivity with the MOb as a seed to the whole brain indicated that HD versus LD had decreased functional connectivity between the VmPFC and MOb during stress (WBC, p < 0.05). In addition, those with more compromised functional connectivity between the VmPFC and MOb during stress consumed greater amount of alcohol beverage during an experimental alcohol taste test conducted on a separate day, as well as in their self-reported weekly alcohol intake. Together, these results indicate that stress-related, dysfunctional VmPFC control over brain regions of autonomic arousal contributes to greater alcohol motivation and may be a significant risk factor for hazardous alcohol use in non-dependent social drinkers. Findings also suggest that restoring VmPFC integrity in modulating autonomic arousal during stress may be critical for preventing the development of AUD.
- Neural correlates linking trauma and physical symptomsPublication . Choi, Justin J.; Martins, Jorge S.; Hwang, Seungju; Sinha, Rajita; Seo, DongjuHighlights •Trauma patients showed greater physical health symptoms and decreased prefrontal but increased hippocampal responses to stress than controls.•More frequent physical symptoms were associated with an increased left hippocampal response to stress.•Trauma may increase physical health symptoms by compromising hippocampal function, which could also increase vulnerability to comorbid stress- and pain-related disorders.
- Sweating it out: The influence of sex and emotions on human sweat productionPublication . Gomes, Nuno; Benrós, Miguel F.; Martins, Jorge S.; Semin, Gün R.; Semin, Gün Refik; Gomes, NunoHuman sweat conveys a wealth of information about its donors, including their emotional state at the time of release. While extensive research has examined the communicative potential of human sweat, the mechanisms underlying emotional sweat production remain underexplored. This study employed a data-driven approach with a large sample of sweat donors (N = 334; most participants were university students) to investigate the relation between sweat production and the emotional state of males and females across three conditions – fear, happiness, and rest. Four key questions were addressed: (i) Do males produce more sweat than females across emotional conditions? (ii) Does sweat production vary as a function of emotional experience? (iii) Is sweat production associated with self-ratings of emotional experience? and (iv) Are there sex differences in these associations? Results revealed that males produced significantly more sweat than females in fear-inducing conditions, which also showed the highest overall sweat production. Contrary to prior findings, happiness-related sweat production did not exceed that of rest in either sex, a discrepancy potentially due to contextual factors. Moreover, sweat production was positively associated with reported negative emotional experience during the fear-inducing sessions, but only for males. This suggests that male, but not female, donors may have the capacity to encode emotional intensity in sweat production. These findings provide new insights into the physiological and contextual factors that shape emotional communication through sweat, with potentially important implications for future research. Additionally, the observed sex asymmetries are discussed in light of a possible evolutionary explanation.