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Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish

2025-03-30Journal article Open access
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorEspigares, Felipe
dc.contributor.authorAlvarado, M. Victoria
dc.contributor.authorAbad-Tortosa, Diana
dc.contributor.authorVarela, Susana A. M.
dc.contributor.authorSobral, Daniel
dc.contributor.authorFaísca, Pedro
dc.contributor.authorPaixão, Tiago
dc.contributor.authorOliveira, Rui
dc.date.accessioned2025-07-02T14:04:27Z
dc.date.available2025-07-02T14:04:27Z
dc.date.issued2025-03-30
dc.description.abstractCognitive judgement bias in decision-making under ambiguity occurs both in animals and humans, with some individuals interpreting ambiguous stimulus as positive (optimism) and others as negative (pessimism). We hypothesize that judgement bias is a personality trait and that individuals with a pessimistic bias would be more reactive to stressors and therefore more susceptible to stress-related diseases than optimistic ones. Here, we show that zebrafish judgment bias is a consistent behavioral trait over time, and that pessimistic and optimistic fish express phenotype-specific neurogenomic responses to stress. Furthermore, both phenotypes show differential activation of the hypothalamic-pituitary-interrenal axis in response to chronic stress, suggesting that optimists have a lower stress reactivity. Accordingly, optimists seem to be more resilient to disease than pessimists, as shown by a lower tumorigenesis in a zebrafish melanoma line [Tg(mtifa:HRAS-GFP)]. Together these results indicate that judgement bias is paralleled by differences in the stress response with implications for disease resilience.eng
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCT
dc.identifier.citationEspigares, F., Alvarado, M. V., Abad-Tortosa, D., Varela, S. A. M., Sobral, D., Faísca, P., Paixão, T., & Oliveira, R. F. (2025). Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish. Translational Psychiatry, 15(1). https://doi.org/10.1038/s41398-025-03311-9
dc.identifier.doi10.1038/s41398-025-03311-9
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/10400.12/13550
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Science and Business Media LLC
dc.relationPTDC/BIA-COM/31010/2017
dc.relation.hasversionhttps://www.nature.com/articles/s41398-025-03311-9
dc.relation.ispartofTranslational Psychiatry
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.titleOptimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleTranslational Psychiatry
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameOliveira
person.givenNameRui
person.identifier.ciencia-id611C-50AD-6CE7
person.identifier.orcid0000-0003-1528-618X
person.identifier.ridA-3581-2013
person.identifier.scopus-author-id35561080400
relation.isAuthorOfPublication52f01205-dce9-433b-85c5-6390488b1eee
relation.isAuthorOfPublication.latestForDiscovery52f01205-dce9-433b-85c5-6390488b1eee

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