A carregar...
Publicação
Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 2.18 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Cognitive judgement bias in decision-making under ambiguity occurs both in animals and humans, with some individuals interpreting ambiguous stimulus as positive (optimism) and others as negative (pessimism). We hypothesize that judgement bias is a personality trait and that individuals with a pessimistic bias would be more reactive to stressors and therefore more susceptible to stress-related diseases than optimistic ones. Here, we show that zebrafish judgment bias is a consistent behavioral trait over time, and that pessimistic and optimistic fish express phenotype-specific neurogenomic responses to stress. Furthermore, both phenotypes show differential activation of the hypothalamic-pituitary-interrenal axis in response to chronic stress, suggesting that optimists have a lower stress reactivity. Accordingly, optimists seem to be more resilient to disease than pessimists, as shown by a lower tumorigenesis in a zebrafish melanoma line [Tg(mtifa:HRAS-GFP)]. Together these results indicate that judgement bias is paralleled by differences in the stress response with implications for disease resilience.
Descrição
Palavras-chave
Contexto Educativo
Citação
Espigares, F., Alvarado, M. V., Abad-Tortosa, D., Varela, S. A. M., Sobral, D., Faísca, P., Paixão, T., & Oliveira, R. F. (2025). Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish. Translational Psychiatry, 15(1). https://doi.org/10.1038/s41398-025-03311-9
Editora
Springer Science and Business Media LLC