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Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder

2023Journal article Open access
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dc.contributor.authorXavier Santos, João
dc.contributor.authorSampaio, Pedro
dc.contributor.authorRasga, Célia
dc.contributor.authorMartiniano, Hugo
dc.contributor.authorFarias, Clarissa
dc.contributor.authorCafé, Cátia
dc.contributor.authorOliveira, Alexandra
dc.contributor.authorDuque, F
dc.contributor.authorOliveira, Guiomar
dc.contributor.authorSOUSA, LISETE
dc.contributor.authorNunes, Ana
dc.contributor.authorVicente, Astrid M
dc.date.accessioned2024-10-16T18:53:12Z
dc.date.available2024-10-16T18:53:12Z
dc.date.issued2023
dc.description.abstractEarly-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of early-life exposure to PM in ASD clinical severity.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, J. X., Sampaio, P., Rasga, C., Martiniano, H., Faria, C., Café, C., Oliveira, A., Duque, F., Oliveira, G., Sousa, L., Nunes, A., & Vicente, A. M. (2023). Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder. Environmental Research, 228. https://doi.org/10.1016/j.envres.2023.115795pt_PT
dc.identifier.doi10.1016/j.envres.2023.115795pt_PT
dc.identifier.issn10960953
dc.identifier.urihttp://hdl.handle.net/10400.12/9989
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAcademic Press Inc.pt_PT
dc.relationPTDC/MED-OUT/28937/2017pt_PT
dc.relationUIDB/04046/2020pt_PT
dc.relationUIDP/04046/2020pt_PT
dc.relationUIDB/00006/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAir pollutionpt_PT
dc.subjectAutism spectrum disorderpt_PT
dc.subjectClinical severitypt_PT
dc.subjectEarly-life exposurept_PT
dc.subjectParticulate matterpt_PT
dc.subjectPregnancypt_PT
dc.titleEvidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Statespt_PT
oaire.citation.startPage115795pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume228pt_PT
person.familyNameXavier dos Santos
person.familyNameMartins de Almeida Sampaio
person.familyNameMaria Rasga
person.familyNameFarias
person.familyNameCafé
person.familyNamede Oliveira Duque
person.familyNameOliveira
person.familyNameRIBEIRO DE SOUSA
person.familyNameda Rocha Nunes
person.familyNameMoura Vicente
person.givenNameJoão Pedro
person.givenNamePedro Rafael
person.givenNameCélia
person.givenNameClarissa
person.givenNameCátia
person.givenNameFrederico José
person.givenNameGuiomar
person.givenNameLISETE MARIA
person.givenNameAna Catarina
person.givenNameAstrid
person.identifierH-3692-2014
person.identifierM-1842-2015
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person.identifier.ridF-8692-2014
person.identifier.scopus-author-id23093713700
person.identifier.scopus-author-id24802739400
person.identifier.scopus-author-id7005820790
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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