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Oxytocin modulates neural activity during early perceptual salience attribution

2024Journal article Open access
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dc.contributor.authorSantiago, Andreia F.
dc.contributor.authorKosilo, Maciej
dc.contributor.authorCogoni, Carlotta
dc.contributor.authorDiogo, Vasco
dc.contributor.authorJerónimo, Rita
dc.contributor.authorPrata, Diana
dc.date.accessioned2024-02-02T16:27:24Z
dc.date.available2024-02-02T16:27:24Z
dc.date.issued2024
dc.description.abstractLeading hypotheses of oxytocin’s (OT) role in human cognition posit that it enhances salience attribution. However, whether OT exerts its effects predominantly in social (vs non-social) contexts remains debatable, and the time-course of intranasal OT’s effects’ on salience attribution processing is still unknown. We used the social Salience Attribution Task modified (sSAT) in a double-blind, placebo-controlled intranasal OT (inOT) administration, between-subjects design, with 54 male participants, to test existing theories of OT’s role in cognition. Namely, we aimed to test whether inOT would differently affect salience attribution processing of social stimuli (expressing fearfulness) and non-social stimuli (fruits) made relevant via monetary reinforcement, and its neural processing time-course. During electroencephalography (EEG) recording, participants made speeded responses to emotional social (fearful faces) and non-emotional non-social (fruits) stimuli - which were matched for task-relevant motivational salience through their (color-dependent) probability of monetary reinforcement. InOT affected early (rather than late, P3b and LPP) EEG components, increasing N170 amplitude (p = .041) and P2b latency (p .001; albeit not of P1), regardless of stimuli’s (emotional) socialness or reinforcement probability. Fear-related socialness affected salience attribution processing EEG (p .05) across time (N170, P2b and P3b), being later modulated by reinforcement probability (LPP). Our data suggest that OT’s effects on neural activity during early perception, may exist irrespective of fear-related social- or reward-contexts. This partially supports the tri-phasic model of OT (which posits OT enhances salience attribution in an early perception stage regardless of socialness), and not the social salience nor the general approach-withdrawal hypotheses of OT, for early salience processing event-related potentials.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantiago, A. F., Kosilo, M., Cogoni, C., Diogo, V., Jerónimo, R., & Prata, D. (2024). Oxytocin modulates neural activity during early perceptual salience attribution. Psychoneuroendocrinology, 161. https://doi.org/10.1016/j.psyneuen.2023.106950pt_PT
dc.identifier.doi10.1016/j.psyneuen.2023.106950pt_PT
dc.identifier.issn18733360
dc.identifier.urihttp://hdl.handle.net/10400.12/9533
dc.language.isospapt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier Ltd.pt_PT
dc.relationLISBOA-01–0145-FEDER-030907pt_PT
dc.relationFP7-PEOPLE-2013-CIG 631952pt_PT
dc.relationEXPL/PSI-GER/1148/2021pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOxytocinpt_PT
dc.subjectMotivationpt_PT
dc.subjectEmotionpt_PT
dc.subjectSocial saliencept_PT
dc.subjectReinforcement learningpt_PT
dc.subjectERPpt_PT
dc.titleOxytocin modulates neural activity during early perceptual salience attributionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Kingdompt_PT
oaire.citation.startPage106950pt_PT
oaire.citation.titlePsychoneuroendocrinologypt_PT
oaire.citation.volume161pt_PT
person.familyNameKosilo
person.familyNameCogoni
person.familyNameDiogo
person.familyNameJerónimo
person.familyNamePinto Prata
person.givenNameMaciej
person.givenNameCarlotta
person.givenNameVasco
person.givenNameRita
person.givenNameDiana Maria
person.identifierYaC5f4AAAAAJ&hl
person.identifier.ciencia-idA21E-E2D0-25FB
person.identifier.ciencia-id8211-12C4-FF1C
person.identifier.ciencia-id7B18-C8FC-904C
person.identifier.orcid0000-0002-5254-1859
person.identifier.orcid0000-0002-7965-9013
person.identifier.orcid0000-0002-7905-3716
person.identifier.orcid0000-0002-4051-022X
person.identifier.scopus-author-id14632352500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication422e05f4-9353-4ffc-a79b-a6513b5b1c7f
relation.isAuthorOfPublication882e7e99-a949-40d8-af75-9a0adde09167
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relation.isAuthorOfPublicationcdbfa810-70b6-40af-b8b0-7a6a4333a6dd
relation.isAuthorOfPublication.latestForDiscovery882e7e99-a949-40d8-af75-9a0adde09167

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