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Publicação
A time to remember: The role of circadian clocks in learning and memory
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| 1.7 MB | Adobe PDF |
Orientador(es)
Resumo(s)
The circadian system has pronounced influence on learning and memory, manifesting as marked changes
in memory acquisition and recall across the day. From a mechanistic perspective, the majority of studies
have investigated mammalian hippocampal-dependent learning and memory, as this system is highly
tractable. The hippocampus plays a major role in learning and memory, and has the potential to integrate
circadian information in many ways, including information from local, independent oscillators, and
through circadian modulation of neurogenesis, synaptic remodeling, intracellular cascades, and epigenetic
regulation of gene expression. These local processes are combined with input from other oscillatory
systems to synergistically augment hippocampal rhythmic function. This overview presents an account
of the current state of knowledge on circadian interactions with learning and memory circuitry and
provides a framework for those interested in further exploring these interactions.
Descrição
Palavras-chave
Daily Recall Hormones Neurogenesis Hippocampus
Contexto Educativo
Citação
Behavioral Neuroscience, 128, 283-303
Editora
American Psychological Association