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Innate chemical, but not visual, threat cues have been co‐opted as unconditioned stimulus for social fear learning in zebrafish

2020Journal article Open access
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dc.contributor.authorPinho, Julia S.
dc.contributor.authorCastilho, Marisa
dc.contributor.authorSollari, Joao S.
dc.contributor.authorOliveira, Rui Filipe
dc.date.accessioned2020-10-27T23:55:03Z
dc.date.available2020-10-27T23:55:03Z
dc.date.issued2020
dc.description.abstractAnimals can use social information to detect threat in the environment. In particular, social learning allows animals to learn about dangers without incurring in the costs of trial-and-error learning. In zebrafish, both chemical and visual social cues elicit an innate alarm response, which consists of erratic movement followed by freezing behavior. Injured zebrafish release an alarm substance from their skin that elicits the alarm response. Similarly, the sight of conspecifics displaying the alarm response can also elicit the expression of this response in observers. In this study, we investigated if these social cues of danger can also be used by zebrafish as unconditioned stimulus (US) in learning. We found that only the chemical cue was effective in the social fear conditioning. We suggest that this differential efficacy of social cues results from the fact that the alarm cue is a more reliable indicator of threat, than the sight of an alarmed conspecific. Therefore, although multiple social cues may elicit innate responses not all have been evolutionarily co-opted to act as US in associative learning. Furthermore, the use of the expression of the immediate early genes as markers of neuronal activity showed that chemical social fear conditioning is paralleled by a differential activation of the olfactory bulbs and by a different pattern of functional connectivity across brain regions involved in olfactory processing.pt_PT
dc.description.sponsorshipFCT - Fundação para a Ciência e Tecnologiapt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGenes, brain and behaviour Doi: 10.1111/gbb.12688pt_PT
dc.identifier.doi10.1111/gbb.12688pt_PT
dc.identifier.issn1601183X
dc.identifier.urihttp://hdl.handle.net/10400.12/7814
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-Blackwell Publishing Ltdpt_PT
dc.relationPTDC/BIAANM/ 0810/2014pt_PT
dc.relationNEUROBEHAVIOURALMECHANISMS INVOLVED IN SOCIAL AND ASOCIAL LEARNING - NEUROBEHAVIOURAL AND MOLECULAR MECHANISMS OF SOCIAL LEARNING IN ZEBRAFISH
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlarm substancept_PT
dc.subjectObservational conditioningpt_PT
dc.subjectOlfactory systempt_PT
dc.subjectSocial fear conditioningpt_PT
dc.subjectSocial learningpt_PT
dc.subjectZebrafishpt_PT
dc.titleInnate chemical, but not visual, threat cues have been co‐opted as unconditioned stimulus for social fear learning in zebrafishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNEUROBEHAVIOURALMECHANISMS INVOLVED IN SOCIAL AND ASOCIAL LEARNING - NEUROBEHAVIOURAL AND MOLECULAR MECHANISMS OF SOCIAL LEARNING IN ZEBRAFISH
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97442%2F2013/PT
oaire.citation.conferencePlaceUnited Kindonpt_PT
oaire.citation.endPage11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleGenes, Brain and Behaviorpt_PT
person.familyNameOliveira
person.givenNameRui
person.identifier.ciencia-id611C-50AD-6CE7
person.identifier.orcid0000-0003-1528-618X
person.identifier.ridA-3581-2013
person.identifier.scopus-author-id35561080400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication52f01205-dce9-433b-85c5-6390488b1eee
relation.isAuthorOfPublication.latestForDiscovery52f01205-dce9-433b-85c5-6390488b1eee
relation.isProjectOfPublication01ea44fc-5883-4880-828c-1a0e85f043cc
relation.isProjectOfPublication.latestForDiscovery01ea44fc-5883-4880-828c-1a0e85f043cc

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