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Oxytocin receptor signaling modulates novelty recognition but not social preference in zebrafish

2020Journal article Restricted access
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dc.contributor.authorRibeiro, Diogo
dc.contributor.authorNunes, Ana Rita
dc.contributor.authorGligsberg, Michael
dc.contributor.authorAnbalagan, Savani
dc.contributor.authorLevkowitz, Gil
dc.contributor.authorOliveira, Rui
dc.date.accessioned2020-01-30T19:00:24Z
dc.date.available2020-01-30T19:00:24Z
dc.date.issued2020
dc.description.abstractSociality is a complex phenomenon that involves the individual's motivation to approach their conspecifics, along with social cognitive functions that enable individuals to interact and survive. The nonapeptide oxytocin (OXT) is known to regulate sociality in many species. However, the role of OXT in specific aspects of sociality is still not well understood. In the present study we investigated the contribution of the OXT receptor (OXTR) signaling in two different aspects of zebrafish social behavior: social preference, by measuring their motivation to approach a shoal of conspecifics, and social recognition, by measuring their ability to discriminate between a novel and familiar fish, using a mutant zebrafish lacking a functional OXTR. Although oxtr mutant zebrafish displayed normal attraction to a shoal of conspecifics, they exhibited reduced social recognition. We further investigated if this effect would be social-domain specific by replacing conspecific fish by objects. Although no differences were observed in object approach, oxtr mutant fish also exhibited impaired object recognition. Our findings suggest that OXTR signaling regulates a more general memory recognition of familiar vs. novel entities, not only in social but also in a non-social domain, in zebrafish.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationJournal of Neuroendocrinology Doi:10.1111/jne.12834pt_PT
dc.identifier.doi10.1111/jne.12834pt_PT
dc.identifier.issn09538194
dc.identifier.urihttp://hdl.handle.net/10400.12/7368
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationSearching for the social brain in a model organism: unveiling the neural circuitry underlying social cognition in zebrafish
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectOxytocinpt_PT
dc.subjectSocial recognitionpt_PT
dc.subjectSocial preferencept_PT
dc.subjectZebrafishpt_PT
dc.subjectAutism spectrum disorderspt_PT
dc.titleOxytocin receptor signaling modulates novelty recognition but not social preference in zebrafishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSearching for the social brain in a model organism: unveiling the neural circuitry underlying social cognition in zebrafish
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F93317%2F2013/PT
oaire.citation.conferencePlaceUnited Kingdompt_PT
oaire.citation.endPage27pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Neuroendocrinologypt_PT
oaire.fundingStreamOE
person.familyNameRibeiro
person.familyNameLevkowitz
person.familyNameTeixeira oliveira
person.givenNameDiogo
person.givenNameGil
person.givenNameRui Filipe
person.identifier74371
person.identifier.ciencia-id5611-5DC0-F794
person.identifier.ciencia-idC818-F08F-A234
person.identifier.orcid0000-0001-6199-3120
person.identifier.orcid0000-0002-3896-1881
person.identifier.orcid0000-0001-8453-5894
person.identifier.scopus-author-id6602661063
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationadbd53ab-9b1e-4c34-ba89-4eebee02caa6
relation.isAuthorOfPublication832c77f5-baab-447d-86d1-8f65f05bb774
relation.isAuthorOfPublication71a73098-4dda-445c-8d85-e08a48c3d12f
relation.isAuthorOfPublication.latestForDiscovery71a73098-4dda-445c-8d85-e08a48c3d12f
relation.isProjectOfPublication08279ab8-f8cc-4a90-a23e-16be75af6a37
relation.isProjectOfPublication.latestForDiscovery08279ab8-f8cc-4a90-a23e-16be75af6a37

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