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Advisor(s)
Abstract(s)
In this paper, we review updated data on sex and gender differences in stress reactivity,
concerning the hypothalamic–pituitary–adrenal axis, endocrinological dysfunction and
vulnerability to major psychiatric disorders, in a stress-diathesis approach. Mainly
schizophrenia and affective disorders are discussed, according to recent investigation,
in terms of early determinants of stress reactivity, the interplay of genetic expression and
gender role, their responsibility in biological modulation and their hypothetical
contribution to explain gender differences in prevalence and clinical aspects of mental
disorders.
Description
Keywords
endocrine dysfunction gender mental disorders sex stress
Citation
Currente Opinion Psychiatry, 23, 369–372
Publisher
Lippincott Williams & Wilkins