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Brucella ceti in Common Dolphins (Delphinus delphis) in Portugal—Characterization of first Isolates

2025-01-28Journal article Open access
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datacite.subject.fosCiências Naturais
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorCavaco, Sandra
dc.contributor.authorGrilo, Miguel
dc.contributor.authorDias, Ricardo
dc.contributor.authorNunes, Mónica
dc.contributor.authorPascoal, Pedro
dc.contributor.authorPereira, Marcelo
dc.contributor.authorFogaça, Catarina
dc.contributor.authorCosta, Ana Beatriz
dc.contributor.authorPardal, Sofia
dc.contributor.authorFerreira, Ana Cristina
dc.date.accessioned2025-06-27T14:24:59Z
dc.date.available2025-06-27T14:24:59Z
dc.date.issued2025-01-28
dc.description.abstract<jats:p>This study investigates Brucella ceti infection in marine mammals stranded along the Lisbon and Tagus Valley coast between 2022 and mid-2024, marking the first report of Brucella presence in Portuguese waters. Out of 59 examined marine mammals, B. ceti was isolated in three common dolphins (5.1%), a prevalence rate consistent with previous studies from other coastlines. PCR-based detection indicated a higher infection rate (23.7%), suggesting an underestimation of the prevalence of B. ceti infection in this population. Multi-locus Sequence Typing (MLST) and Multiple-Locus Variable-Number Tandem-Repeat Analysis (MLVA) revealed distinct genetic profiles and close relationships to B. ceti strains from the Atlantic, supporting the hypothesis of specific host-adapted lineages in dolphins. Virulence genes, including those for host interaction (bspE, btpB) and intracellular survival (virB7, vceA), were consistent across isolates, highlighting the pathogenic potential. Additionally, antimicrobial resistance (AMR) genes, such as mprF and efflux proteins (bepC-G), were also identified. These findings underscore the need for further research and surveillance to understand B. ceti transmission, host range, and impacts on Atlantic cetaceans, as well as to develop effective diagnostic and management strategies to mitigate infection risks in marine environments.</jats:p>
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCT
dc.identifier.citationCavaco, S., Ferreira, A. C., Grilo, M. L., Fogaça, C., Costa, A. B., Pardal, S., Dias, R., Nunes, M., Pascoal, P., & Pereira, M. (2025). Brucella ceti in Common Dolphins (Delphinus delphis) in Portugal—Characterization of First Isolates. Animals, 15(3). https://doi.org/10.3390/ani15030374
dc.identifier.doi10.3390/ani15030374
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10400.12/13546
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI AG
dc.relationUID/04046/2025
dc.relationUIDB/00329/2020
dc.relation.hasversionhttps://www.mdpi.com/2076-2615/15/3/374
dc.relation.ispartofAnimals
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleBrucella ceti in Common Dolphins (Delphinus delphis) in Portugal—Characterization of first Isolateseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.titleAnimals
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGrilo
person.givenNameMiguel
person.identifier.ciencia-id4B17-DF6F-1A51
person.identifier.orcid0000-0001-7364-821X
person.identifier.scopus-author-id57195729611
relation.isAuthorOfPublication23ef9ada-f98f-4fff-9368-8f54cf6bdbe1
relation.isAuthorOfPublication.latestForDiscovery23ef9ada-f98f-4fff-9368-8f54cf6bdbe1

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