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Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish

2020Journal article Open access
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dc.contributor.authorRibeiro, Diogo
dc.contributor.authorNunes, Ana Rita
dc.contributor.authorTeles, Magda C
dc.contributor.authorAnbalagan, Savani
dc.contributor.authorBlechman, Janna
dc.contributor.authorLevkowitz, Gil
dc.contributor.authorOliveira, Rui Filipe
dc.date.accessioned2020-10-23T14:55:13Z
dc.date.available2020-10-23T14:55:13Z
dc.date.issued2020
dc.description.abstractOxytocin-like peptides have been implicated in the regulation of a wide range of social behaviors across taxa. On the other hand, the social environment, which is composed of conspecifics that may vary in their genotypes, also influences social behavior, creating the possibility for indirect genetic effects. Here, we used a zebrafish oxytocin receptor knockout line to investigate how the genotypic composition of the social environment (Gs) interacts with the oxytocin genotype of the focal individual (Gi) in the regulation of its social behavior. For this purpose, we have raised wild-type or knock-out zebrafish in either wild-type or knock-out shoals and tested different components of social behavior in adults. GixGs effects were detected in some behaviors, highlighting the need to control for GixGs effects when interpreting results of experiments using genetically modified animals, since the genotypic composition of the social environment can either rescue or promote phenotypes associated with specific genes.pt_PT
dc.description.sponsorshipFCT - Fundação para a Ciência e Tecnologiapt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationeLife, 9, 1-10 Doi: 10.7554/eLife.56973pt_PT
dc.identifier.doi10.7554/eLife.56973pt_PT
dc.identifier.issn2050084X
dc.identifier.urihttp://hdl.handle.net/10400.12/7809
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publishereLife Sciences Publicationspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleGenetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-ANM%2F0810%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F93317%2F2013/PT
oaire.citation.conferencePlaceUnited kindonpt_PT
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleeLifept_PT
oaire.citation.volume9pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameNunes
person.familyNameTeles
person.familyNameAnbalagan
person.familyNameLevkowitz
person.familyNameOliveira
person.givenNameAna Rita
person.givenNameMagda C
person.givenNameSavani
person.givenNameGil
person.givenNameRui
person.identifier74371
person.identifier.ciencia-idEE14-5768-A5AE
person.identifier.ciencia-idE81E-61AE-44BC
person.identifier.ciencia-id5611-5DC0-F794
person.identifier.ciencia-id611C-50AD-6CE7
person.identifier.orcid0000-0003-4108-5322
person.identifier.orcid0000-0002-3051-8332
person.identifier.orcid0000-0003-4839-9439
person.identifier.orcid0000-0002-3896-1881
person.identifier.orcid0000-0003-1528-618X
person.identifier.ridA-3581-2013
person.identifier.scopus-author-id16200314100
person.identifier.scopus-author-id6602661063
person.identifier.scopus-author-id35561080400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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