Repository logo
 
Publication

Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers

2023Journal article Restricted access
Simple item page
dc.contributor.authorWemm, Stephanie
dc.contributor.authorGolden, Max
dc.contributor.authorS. Martins, Jorge
dc.contributor.authorFogelman, Nia
dc.contributor.authorSinha, Rajita
dc.date.accessioned2024-03-18T19:56:46Z
dc.date.available2024-03-18T19:56:46Z
dc.date.issued2023
dc.description.abstractChronic heavy alcohol use profoundly affects the cardiovascular system, contributing to several life-threatening cardiovascular diseases. Heart rate variability (HRV), or the fluctuations in heart rate, reflects dynamic autonomic nervous system processes that change to meet biological demands and environmental challenges. In the current study, we examined whether HRV metrics are altered in alcohol use disorder (AUD) during waking and sleeping with passive biomonitoring as participants went about their daily lives. Social drinkers (standard deviation: n = 10, 5 female) and treatment-seeking individuals with moderate to severe AUD (n = 16, 7 female) provided continuous, real-world heart rate monitoring for 5 days of monitoring on average (M = 5.27 ± 2.22). Five indices of respiration and HRV—respiratory sinus arrhythmia (RSA) amplitude, high frequency (HF), low frequency (LF), HF/LF ratio, root-mean-square standard deviation (RMSSD), and standard deviation of the N–N intervals (SDNN)—were analyzed separately for waking and sleeping hours. Both RMSSD and SDNN decreased the longer the participants were awake (Ps < .013). During sleeping hours, HF, RSA amplitude, RMSSD, and SDNN were significantly higher in light social drinkers as compared to patients with AUD (all Ps < .009), indicating higher parasympathetic activation during sleep in the SD versus AUD group. Sleep and waking HRV measures were significantly correlated with patient-reported symptoms of depression and sleep difficulties in the AUD group (Ps < .05). This natural observational study utilizing continuous autonomic biomonitoring in the real world indicates parasympathetic dysfunction that is clearly detectable during sleep in AUD and HRV measures, which are also related to clinical, patient-related symptoms of AUD.pt_PT
dc.description.sponsorshipNational Institutes of Health (NIH)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWemm, S. E., Martins, J., Fogelman, N., Sinha, R., & Golden, M. (2023). Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol and Alcoholism, 58(6), 653–661. https://doi.org/10.1093/alcalc/agad061pt_PT
dc.identifier.doi10.1093/alcalc/agad061pt_PT
dc.identifier.issn07350414
dc.identifier.urihttp://hdl.handle.net/10400.12/9685
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relationR01-AA013892pt_PT
dc.relationR01-AA026844pt_PT
dc.relationK08- AA023545pt_PT
dc.relationKL2 TR001862pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEthanolpt_PT
dc.subjectHeart rate variabilitypt_PT
dc.subjectAutonomic nervous systempt_PT
dc.subjectHeart failurept_PT
dc.subjectSleeppt_PT
dc.subjectAlcohol use disorderpt_PT
dc.titlePatients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Kingdompt_PT
oaire.citation.endPage661pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage653pt_PT
oaire.citation.titleAlcohol and Alcoholismpt_PT
oaire.citation.volume58pt_PT
person.familyNameWemm
person.familyNameGolden
person.familyNameMartins
person.familyNameFogelman
person.familyNameSINHA
person.givenNameStephanie
person.givenNameMax
person.givenNameJorge
person.givenNameNia
person.givenNameRAJITA
person.identifier.ciencia-id0C1F-8C7C-77DD
person.identifier.orcid0000-0001-8754-7479
person.identifier.orcid0000-0002-3647-4342
person.identifier.orcid0000-0002-1776-8855
person.identifier.orcid0000-0003-0156-7220
person.identifier.orcid0000-0003-3012-4349
person.identifier.scopus-author-id36105440600
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2b71c8a9-bcd8-41b0-b54d-f8aba3681718
relation.isAuthorOfPublication9d0b20d8-739c-4a11-b159-c8ebd1329ee8
relation.isAuthorOfPublication4e8084b7-4932-4a4e-b019-bc23be9e3249
relation.isAuthorOfPublication4e01e5b9-f9fe-4633-85e5-1ea61959c74b
relation.isAuthorOfPublication21bb4ac8-3ad7-4b8b-891c-9bfda45c6c98
relation.isAuthorOfPublication.latestForDiscovery9d0b20d8-739c-4a11-b159-c8ebd1329ee8

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Stephetal.2023.pdf
Size:
721.89 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

WJCR - Artigos em revistas internacionais