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Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial

2021Journal article Open access
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dc.contributor.authorLarsen, Sofus C.
dc.contributor.authorTuricchi, Jake
dc.contributor.authorChristensen, Gitte L.
dc.contributor.authorLarsen, Charlotte S.
dc.contributor.authorJørgensen, Niklas R.
dc.contributor.authorMikkelsen, Marie-Louise K.
dc.contributor.authorHorgan, Graham
dc.contributor.authorO'Driscoll, Ruairi
dc.contributor.authorMichalowska, Joanna
dc.contributor.authorDuarte, Cristiana
dc.contributor.authorScott, Sarah E.
dc.contributor.authorSantos, Inês
dc.contributor.authorEncantado, Jorge
dc.contributor.authorPalmeira, Antonio L.
dc.contributor.authorStubbs, R. James
dc.contributor.authorHeitmann, Berit L.
dc.date.accessioned2022-07-20T13:30:26Z
dc.date.available2022-07-20T13:30:26Z
dc.date.issued2021
dc.description.abstractSeveral cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P =0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability. Clinical Trial Registration: ISRCTN registry, identifier ISRCTN88405328. [ABSTRACT FROM AUTHOR]pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLarsen, S. C., Turicchi, J., Christensen, G. L., Larsen, C. S., Jørgensen, N. R., Mikkelsen, M.-L. K., Horgan, G., O’Driscoll, R., Michalowska, J., Duarte, C., Scott, S. E., Santos, I., Encantado, J., Palmeira, A. L., Stubbs, R. J., & Heitmann, B. L. (2021). Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial. Frontiers in Endocrinology, 12, 1–11.pt_PT
dc.identifier.doi10.3389/fendo.2021.655197pt_PT
dc.identifier.issn16642392
dc.identifier.urihttp://hdl.handle.net/10400.12/8739
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media S.A.pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHair cortisolpt_PT
dc.subjectObesitypt_PT
dc.subjectStresspt_PT
dc.subjectWeight losspt_PT
dc.subjectWeight loss maintenancept_PT
dc.titleHair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Endocrinologypt_PT
oaire.citation.volume12pt_PT
person.familyNameLarsen
person.familyNameturicchi
person.familyNameHorgan
person.familyNameO'Driscoll
person.familyNameConde Encantado Paulo
person.givenNameSofus C.
person.givenNamejake
person.givenNameGraham
person.givenNameRuairi
person.givenNameJorge Eduardo
person.identifier367778
person.identifier.ciencia-id0611-B42E-407D
person.identifier.orcid0000-0002-0838-9378
person.identifier.orcid0000-0001-5504-9037
person.identifier.orcid0000-0002-6048-1374
person.identifier.orcid0000-0003-3995-0073
person.identifier.orcid0000-0003-0542-8340
person.identifier.ridL-4752-2017
person.identifier.scopus-author-id55649568975
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5856245b-d14f-41e9-8c9f-d70e1ce11e4f
relation.isAuthorOfPublication03de3a48-8b2b-42c4-afa6-b28143f09f5e
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relation.isAuthorOfPublicationa9747520-dfea-4eb3-bd33-ae9ba2f1a2d6
relation.isAuthorOfPublication.latestForDiscoveryc93cd4d6-ff2c-4b09-847d-3a7710863b3c

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