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Sex differences in aggression are paralleled by differential activation of the brain social decision-making network in Zebrafish

2022Journal article Open access
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dc.contributor.authorScaia, Maria Florencia
dc.contributor.authorAkinrinade, Ibukun
dc.contributor.authorPetri, Giovanni
dc.contributor.authorOliveira, Rui F.
dc.date.accessioned2022-03-17T20:35:39Z
dc.date.available2022-03-17T20:35:39Z
dc.date.issued2022
dc.description.abstractAlthough aggression is more prevalent in males, females also express aggressive behaviors and in specific ecological contexts females can be more aggressive than males. The aim of this work is to assess sex differences in aggression and to characterize the patterns of neuronal activation of the social-decision making network (SDMN) in response to intra-sexual aggression in both male and female zebrafish. Adult fish were exposed to social interaction with a same-sex opponent and all behavioral displays, latency, and time of resolution were quantified. After conflict resolution, brains were sampled and sex differences on functional connectivity throughout the SDMN were assessed by immunofluorescence of the neuronal activation marker pS6. Results suggest that both sexes share a similar level of motivation for aggression, but female encounters show shorter conflict resolution and a preferential use of antiparallel displays instead of overt aggression, showing a reduction of putative maladaptive effects. Although there are no sex differences in the neuronal activation in any individual brain area from the SDMN, agonistic interactions increased neuronal activity in most brain areas in both sexes. Functional connectivity was assessed using bootstrapped adjacency matrices that capture the co-activation of the SDMN nodes. Male winners increased the overall excitation and showed no changes in inhibition across the SDMN, whereas female winners and both male and female losers showed a decrease in both excitation and inhibition of the SDMN in comparison to non-interacting control fish. Moreover, network centrality analysis revealed both shared hubs, as well as sex-specific hubs, between the sexes for each social condition in the SDMN. In summary, a distinct neural activation pattern associated with social experience during fights was found for each sex, suggesting a sex-specific differential activation of the social brain as a consequence of social experience. Overall, our study adds insights into sex differences in agonistic behavior and on the neuronal architecture of intrasexual aggression in zebrafish.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationScaia, M. F., Akinrinade, I., Petri, G., & Oliveira, R. F. (2022). Sex differences in aggression are paralleled by differential activation of the brain social decision-making network in zebrafish. Frontiers in Behavioral Neuroscience, 16 doi:10.3389/fnbeh.2022.784835pt_PT
dc.identifier.doi10.3389/fnbeh.2022.784835pt_PT
dc.identifier.issn16641078
dc.identifier.urihttp://hdl.handle.net/10400.12/8612
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media S.A.pt_PT
dc.relationDevelopmental and transgenerational effects of oxytocin-like peptides on social behavior: an eco-evo-devo approach using zebrafish as a model
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAggressive behaviorpt_PT
dc.subjectSex-differencespt_PT
dc.subjectSocial decision-making networkpt_PT
dc.subjectContestpt_PT
dc.subjectFishpt_PT
dc.titleSex differences in aggression are paralleled by differential activation of the brain social decision-making network in Zebrafishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopmental and transgenerational effects of oxytocin-like peptides on social behavior: an eco-evo-devo approach using zebrafish as a model
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-COM%2F30627%2F2017/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage15pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Behavioral Neurosciencept_PT
oaire.citation.volume16pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameScaia
person.familyNameAkinrinade
person.familyNamePetri
person.familyNameOliveira
person.givenNameMaria Florencia
person.givenNameIbukun
person.givenNameGiovanni
person.givenNameRui
person.identifier.ciencia-id0319-D788-C2EC
person.identifier.ciencia-id611C-50AD-6CE7
person.identifier.orcid0000-0001-8013-7063
person.identifier.orcid0000-0002-4018-2641
person.identifier.orcid0000-0003-1847-5031
person.identifier.orcid0000-0003-1528-618X
person.identifier.ridA-3581-2013
person.identifier.scopus-author-id55923137600
person.identifier.scopus-author-id35561080400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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