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The polygenic and reactive nature of observed parenting

2023Journal article Open access
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dc.contributor.authorRunze, Jana
dc.contributor.authorBakermans-Kranenburg, Marian
dc.contributor.authorCecil, Charlotte A M
dc.contributor.authorvan IJzendoorn, Marinus
dc.contributor.authorPappa, Irene
dc.date.accessioned2024-02-15T18:44:18Z
dc.date.available2024-02-15T18:44:18Z
dc.date.issued2023
dc.description.abstractIn Wertz et al. (2019), parents' polygenic scores of educational attainment (PGS-EA) predicted parental sensitive responses to the child's needs for support, as observed in a dyadic task (i.e., observed sensitivity). We aimed to replicate and expand these findings by combining longitudinal data, child genotype data and several polygenic scores in the Generation R Study. Mother–child dyads participated in two developmental periods, toddlerhood (14 months old; n = 648) and early childhood (3–4 years old, n = 613). Higher maternal PGS-EA scores predicted higher observed sensitivity in toddlerhood (b = 0.12, 95% CI 0.03, 0.20) and early childhood (b = 0.16, 95% CI 0.08, 0.24). Child PGS-EA was significantly associated with maternal sensitivity in early childhood (b = 0.11, 95% CI 0.02, 0.21), and the effect of maternal PGS-EA was no longer significant when correcting for child PGS-EA. A latent factor of PGSs based on educational attainment, intelligence (IQ) and income showed similar results. These polygenic scores might be associated with maternal cognitive and behavioral skills that help shape parenting. Maternal PGSs predicted observed sensitivity over and above the maternal phenotypes, showing an additional role for PGSs in parenting research. In conclusion, we replicated the central finding of Wertz et al. (2019) that parental PGS-EA partially explains parental sensitivity. Our findings may be consistent with evocative gene–environment correlation (rGE), emphasizing the dynamic nature of parenting behavior across time, although further research using family trios is needed to adequately test this hypothesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRunze, J., Bakermans, K. M. J., Cecil, C. A. M., van IJzendoorn, M. H., & Pappa, I. (2023). The polygenic and reactive nature of observed parenting. Genes, Brain & Behavior, 22(6), 1–12. https://doi.org/10.1111/gbb.12874pt_PT
dc.identifier.doi10.1111/gbb.12874pt_PT
dc.identifier.issn1601183X
dc.identifier.urihttp://hdl.handle.net/10400.12/9580
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-Blackwell Publishing Ltdpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEducational attainmentpt_PT
dc.subjectEvocative gene–environment correlationpt_PT
dc.subjectPaternal sensitivitypt_PT
dc.subjectParenting behaviorpt_PT
dc.subjectPolygenic risk score (PGS)pt_PT
dc.titleThe polygenic and reactive nature of observed parentingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Kingdompt_PT
oaire.citation.issue6pt_PT
oaire.citation.titleGenes, Brain and Behaviorpt_PT
oaire.citation.volume22pt_PT
person.familyNameRunze
person.familyNameBakermans-Kranenburg
person.familyNameCecil
person.familyNamevan IJzendoorn
person.familyNamePappa
person.givenNameJana
person.givenNameMarian
person.givenNameCharlotte
person.givenNameMarinus
person.givenNameIrene
person.identifier111725267
person.identifier.ciencia-id5C11-947F-B345
person.identifier.orcid0000-0003-1792-3357
person.identifier.orcid0000-0001-7763-0711
person.identifier.orcid0000-0002-2389-5922
person.identifier.orcid0000-0003-1144-454X
person.identifier.orcid0000-0003-4936-5791
person.identifier.ridI-7388-2015
person.identifier.ridI-1379-2012
person.identifier.scopus-author-id57463441300
person.identifier.scopus-author-id6701679127
person.identifier.scopus-author-id55347143400
person.identifier.scopus-author-id48161376000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication91a38a26-2df1-4c14-a369-593e98e760de
relation.isAuthorOfPublication07e9b8d8-8d10-44f3-8957-498e24221f7a
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relation.isAuthorOfPublication.latestForDiscovery07e9b8d8-8d10-44f3-8957-498e24221f7a

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