The polygenic and reactive nature of observed parenting

Runze, Jana; Bakermans-Kranenburg, Marian; Cecil, Charlotte A M; van IJzendoorn, Marinus; Pappa, Irene

http://hdl.handle.net/10400.12/9580

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Authors

Runze, Jana

Bakermans-Kranenburg, Marian

Cecil, Charlotte A M

van IJzendoorn, Marinus

Pappa, Irene

Abstract(s)

In Wertz et al. (2019), parents' polygenic scores of educational attainment (PGS-EA) predicted parental sensitive responses to the child's needs for support, as observed in a dyadic task (i.e., observed sensitivity). We aimed to replicate and expand these findings by combining longitudinal data, child genotype data and several polygenic scores in the Generation R Study. Mother–child dyads participated in two developmental periods, toddlerhood (14 months old; n = 648) and early childhood (3–4 years old, n = 613). Higher maternal PGS-EA scores predicted higher observed sensitivity in toddlerhood (b = 0.12, 95% CI 0.03, 0.20) and early childhood (b = 0.16, 95% CI 0.08, 0.24). Child PGS-EA was significantly associated with maternal sensitivity in early childhood (b = 0.11, 95% CI 0.02, 0.21), and the effect of maternal PGS-EA was no longer significant when correcting for child PGS-EA. A latent factor of PGSs based on educational attainment, intelligence (IQ) and income showed similar results. These polygenic scores might be associated with maternal cognitive and behavioral skills that help shape parenting. Maternal PGSs predicted observed sensitivity over and above the maternal phenotypes, showing an additional role for PGSs in parenting research. In conclusion, we replicated the central finding of Wertz et al. (2019) that parental PGS-EA partially explains parental sensitivity. Our findings may be consistent with evocative gene–environment correlation (rGE), emphasizing the dynamic nature of parenting behavior across time, although further research using family trios is needed to adequately test this hypothesis.

Keywords

Educational attainment Evocative gene–environment correlation Paternal sensitivity Parenting behavior Polygenic risk score (PGS)

URI

http://hdl.handle.net/10400.12/9580

Citation

Runze, J., Bakermans, K. M. J., Cecil, C. A. M., van IJzendoorn, M. H., & Pappa, I. (2023). The polygenic and reactive nature of observed parenting. Genes, Brain & Behavior, 22(6), 1–12. https://doi.org/10.1111/gbb.12874