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Adult neurogenesis in the brain of the Mozambique tilapia, Oreochromis mossambicus

2012Journal article Open access
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dc.contributor.authorTeles, Magda C
dc.contributor.authorSîrbulescu, Ruxandra F.
dc.contributor.authorWellbrock, Ursula M.
dc.contributor.authorOliveira, Rui Filipe
dc.contributor.authorZupanc, Günther K. H.
dc.date.accessioned2020-09-18T00:32:26Z
dc.date.available2020-09-18T00:32:26Z
dc.date.issued2012
dc.description.abstractAlthough the generation of new neurons in the adult nervous system ('adult neurogenesis') has been studied intensively in recent years, little is known about this phenomenon in non-mammalian vertebrates. Here, we examined the generation, migration, and differentiation of new neurons and glial cells in the Mozambique tilapia (Oreochromis mossambicus), a representative of one of the largest vertebrate taxonomic orders, the perciform fish. The vast majority of new cells in the brain are born in specific proliferation zones of the olfactory bulb; the dorsal and ventral telencephalon; the periventricular nucleus of the posterior tuberculum, optic tectum, and nucleus recessi lateralis of the diencephalon; and the valvula cerebelli, corpus cerebelli, and lobus caudalis of the cerebellum. As shown in the olfactory bulb and the lateral part of the valvula cerebelli, some of the young cells migrate from their site of origin to specific target areas. Labeling of mitotic cells with the thymidine analog 5-bromo-2'-deoxyuridine, combined with immunostaining against the neuron-specific marker protein Hu or against the astroglial marker glial fibrillary acidic protein demonstrated differentiation of the adult-born cells into both neurons and glia. Taken together, the present investigation supports the hypothesis that adult neurogenesis is an evolutionarily conserved vertebrate trait.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJournal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology,198, 427–449 Doi: 10.1007/s00359-012-0721-6pt_PT
dc.identifier.doi10.1007/s00359-012-0721-6pt_PT
dc.identifier.issn14321351
dc.identifier.urihttp://hdl.handle.net/10400.12/7740
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer-Verlagpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAge Factorspt_PT
dc.subjectAnimalspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBrainpt_PT
dc.subjectCell Differentiationpt_PT
dc.subjectCell Movementpt_PT
dc.subjectCell Proliferationpt_PT
dc.subjectELAV Proteinspt_PT
dc.subjectGlial Fibrillary Acidic Proteinpt_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectMitosispt_PT
dc.subjectNeurogliapt_PT
dc.subjectNeuronspt_PT
dc.subjectTilapiapt_PT
dc.subjectNeurogenesispt_PT
dc.titleAdult neurogenesis in the brain of the Mozambique tilapia, Oreochromis mossambicuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceGermanypt_PT
oaire.citation.endPage449pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage427pt_PT
oaire.citation.titleJournal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiologypt_PT
oaire.citation.volume198pt_PT
person.familyNameTeles
person.familyNameOliveira
person.givenNameMagda C
person.givenNameRui
person.identifier.ciencia-idE81E-61AE-44BC
person.identifier.ciencia-id611C-50AD-6CE7
person.identifier.orcid0000-0002-3051-8332
person.identifier.orcid0000-0003-1528-618X
person.identifier.ridA-3581-2013
person.identifier.scopus-author-id16200314100
person.identifier.scopus-author-id35561080400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication56a9d10c-8d25-4635-a714-03a0eda7fcd4
relation.isAuthorOfPublication52f01205-dce9-433b-85c5-6390488b1eee
relation.isAuthorOfPublication.latestForDiscovery56a9d10c-8d25-4635-a714-03a0eda7fcd4

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