Loading...
Publication
Mecanismos de dor nas espondiloartrites e sua relação com o desempenho cognitivo
Authors
Abstract(s)
Muitos estudos têm demonstrado que a dor e diversos aspetos do funcionamento cognitivo
partilham uma sobreposição inerente, não só porque a dor tem um componente
cognitivo-avaliativo, mas também porque a dor persistente parece estar relacionada com
modificações em redes neuronais utilizadas em processos cognitivos.
Foram recrutados 17 doentes com espondiloartrites num Serviço de Reumatologia, e
realizaram avaliação cognitiva através dos testes Stroop, Fluência Verbal, Memória de
Dígitos, a dor foi dor induzida através do Paradigma da Dor Condicionada. As características
clínicas foram avaliadas pelo BASFI (Bath Ankylosing Spondylitis Functional Index),
BASDAI- (Bath Ankylosing Spondylitis Disease Activity Index), Inquérito de Saúde de
Formulário Curto SF-36, BPI- (Brief Pain Inventory), HADS (Hospital Depression and
Anxiety Scale), e PSQI (The Pittsburgh Sleep Quality Index-The Pittsburgh Sleep Quality
Index).
Os indivíduos com espondiloartrites apresentaram dificuldade nas vias descendentes
anti-nociceptivas na modalidade térmica é a maior percepção de dor no momento do
condicionamento se relaciona com o desempenho na tarefa de fluência verbal. Uma pontuação
mais baixa nesta tarefa cognitiva também se relacionou com uma menor percepção de estado
de saúde nas dimensões sociais e de saúde mental e no sono.
A relação entre as alterações nos mecanismos da dor decorrentes da presença de dor parece
estar relacionada com um desempenho cognitivo mais fraco. No entanto, tais relações
parecem ocorrer em modalidades sensoriais e paradigmas de avaliação de dor, e de
desempenho cognitivo específicos.
Many studies have shown that pain and various aspects of cognitive functioning share an inherent overlap, not only because pain has a cognitive-evaluative component, but also because persistent pain seems to be related to modifications in neuronal networks used in cognitive processes. Seventeen patients with spondyloarthritis were recruited in a Rheumatology Service, and they underwent cognitive assessment through the Stroop, Verbal Fluency, Digit Memory tests, pain induced through the Conditioned Pain Paradigm. Clinical characteristics were assessed by BASFI (Bath Ankylosing Spondylitis Functional Index), BASDAI- (Bath Ankylosing Spondylitis Disease Activity Index), SF-36 Short Form Health Survey, BPI- (Brief Pain Inventory), HADS (Hospital Depression and Anxiety Scale), and PSQI (The Pittsburgh Sleep Quality Index-The Pittsburgh Sleep Quality Index). Individuals with spondyloarthritis showed difficulty in descending anti-nociceptive pathways in the thermal modality is higher pain perception at the time of conditioning correlates with performance on the verbal fluency task. A lower score on this cognitive task also correlated with lower perceived health status in social and mental health dimensions and sleep. The relationship between changes in pain mechanisms due to the presence of pain seems to be related to poorer cognitive performance. However, such relationships appear to occur in specific sensory modalities and pain assessment paradigms, and cognitive performance.
Many studies have shown that pain and various aspects of cognitive functioning share an inherent overlap, not only because pain has a cognitive-evaluative component, but also because persistent pain seems to be related to modifications in neuronal networks used in cognitive processes. Seventeen patients with spondyloarthritis were recruited in a Rheumatology Service, and they underwent cognitive assessment through the Stroop, Verbal Fluency, Digit Memory tests, pain induced through the Conditioned Pain Paradigm. Clinical characteristics were assessed by BASFI (Bath Ankylosing Spondylitis Functional Index), BASDAI- (Bath Ankylosing Spondylitis Disease Activity Index), SF-36 Short Form Health Survey, BPI- (Brief Pain Inventory), HADS (Hospital Depression and Anxiety Scale), and PSQI (The Pittsburgh Sleep Quality Index-The Pittsburgh Sleep Quality Index). Individuals with spondyloarthritis showed difficulty in descending anti-nociceptive pathways in the thermal modality is higher pain perception at the time of conditioning correlates with performance on the verbal fluency task. A lower score on this cognitive task also correlated with lower perceived health status in social and mental health dimensions and sleep. The relationship between changes in pain mechanisms due to the presence of pain seems to be related to poorer cognitive performance. However, such relationships appear to occur in specific sensory modalities and pain assessment paradigms, and cognitive performance.
Description
Dissertação de Mestrado apresentada no ISPA – Instituto
Universitário para obtenção de grau de Mestre em
Neurociências na especialidade de Neurociências
Cognitivas e Comportamentais.
Keywords
Dor Espondiloartrite Comprometimento cognitivo Paradigma da dor condicionada Pain Spondyloarthritis Cognitive impairment Conditioned pain paradigm