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The free and cued selective reminding test for predicting progression to alzheimer's disease in patients with mild cognitive impairment: A prospective longitudinal study

2017Journal article Restricted access
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dc.contributor.authorLemos, Raquel
dc.contributor.authorMaroco, João
dc.contributor.authorSimões, Mário R.
dc.contributor.authorSantiago, Beatriz
dc.contributor.authorTomás, José
dc.contributor.authorSantana, Isabel
dc.date.accessioned2017-03-23T18:18:16Z
dc.date.available2017-03-23T18:18:16Z
dc.date.issued2017
dc.description.abstractAmnestic mild cognitive impairment (aMCI) patients carry a greater risk of conversion to Alzheimer's disease (AD). Therefore, the International Working Group (IWG) on AD aims to consider some cases of aMCI as symptomatic prodromal AD. The core diagnostic marker of AD is a significant and progressive memory deficit, and the Free and Cued Selective Reminding Test (FCSRT) was recommended by the IWG to test memory in cases of possible prodromal AD. This study aims to investigate whether the performance on the FCSRT would enhance the ability to predict conversion to AD in an aMCI group. A longitudinal study was conducted on 88 aMCI patients, and neuropsychological tests were analysed on the relative risk of conversion to AD. During follow-up (23.82 months), 33% of the aMCI population converted to AD. An impaired FCSRT TR was significantly associated with the risk of conversion to dementia, with a mean time to conversion of 25 months. The FCSRT demonstrates utility for detecting AD at its prodromal stage, thus supporting its use as a valid clinical marker.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJournal Of Neuropsychology, 11(1), 40-55. Doi:10.1111/jnp.12075pt_PT
dc.identifier.doi10.1111/jnp.12075pt_PT
dc.identifier.issn1748-6645
dc.identifier.urihttp://hdl.handle.net/10400.12/5345
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationEarly Diagnosis of Alzheimer´s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/jnp.12075/abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectFree and cued selective reminding testpt_PT
dc.subjectMild cognitive impairmentpt_PT
dc.subjectAlzheimer's diseasept_PT
dc.subjectProgressionpt_PT
dc.titleThe free and cued selective reminding test for predicting progression to alzheimer's disease in patients with mild cognitive impairment: A prospective longitudinal studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEarly Diagnosis of Alzheimer´s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F74070%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PIC%2FIC%2F83206%2F2007/PT
oaire.citation.conferencePlaceUnited Statespt_PT
oaire.citation.endPage55pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage40pt_PT
oaire.citation.titleJournal of Neuropsychologypt_PT
oaire.citation.volume11pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream5876-PPCDTI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication3da70471-84be-4878-8280-7d9120828d69
relation.isProjectOfPublicationde283889-2c77-46e8-afb7-14c57f67a7cc
relation.isProjectOfPublication.latestForDiscoveryde283889-2c77-46e8-afb7-14c57f67a7cc

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