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Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain

2016Journal article Restricted access
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dc.contributor.authorOliveira, Rui Filipe
dc.contributor.authorSimões, José Miguel
dc.contributor.authorTeles, Magda
dc.contributor.authorOliveira, Catarina R.
dc.contributor.authorBecker, Jorg D.
dc.contributor.authorLopes, João Sollari
dc.date.accessioned2016-04-06T14:03:22Z
dc.date.available2016-04-06T14:03:22Z
dc.date.issued2016
dc.description.abstractGroup living animals must be able to express different behavior profiles depending on their social status. Therefore, the same genotype may translate into different behavioral phenotypes through socially driven differential gene expression. However, how social information is translated into a neurogenomic response and what are the specific cues in a social interaction that signal a change in social status are questions that have remained unanswered. Here, we show for the first time, to our knowledge, that the switch between status-specific neurogenomic states relies on the assessment of fight outcome rather than just on self- or opponent-only assessment of fighting ability. For this purpose, we manipulated the perception of fight outcome in male zebrafish and measured its impact on the brain transcriptome using a zebrafish whole genome gene chip. Males fought either a real opponent, and a winner and a loser were identified, or their own image on a mirror, in which case, despite expressing aggressive behavior, males did not experience either a victory or a defeat. Massive changes in the brain transcriptome were observed in real opponent fighters, with losers displaying both a higher number of differentially expressed genes and of coexpressed gene modules than winners. In contrast, mirror fighters expressed a neurogenomic state similar to that of noninteracting fish. The genes that responded to fight outcome included immediate early genes and genes involved in neuroplasticity and epigenetic modifications. These results indicate that, even in cognitively simple organisms such as zebrafish, neurogenomic responses underlying changes in social status rely on mutual assessment of fighting ability.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)pt_PT
dc.identifier.citationProceedings of the National Academy of Sciences, 113, 654-661. doi:10.1073/pnas.1514292113pt_PT
dc.identifier.doi10.1073/pnas.1514292113pt_PT
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/10400.12/4518
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Academy of Sciencept_PT
dc.relationMolecular mechanisms and evolutionary implications of social plasticity
dc.subjectSocial dominancept_PT
dc.subjectMutual assessmentpt_PT
dc.subjectFightingpt_PT
dc.subjectGene expressionpt_PT
dc.subjectSocial genomicspt_PT
dc.titleAssessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brainpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular mechanisms and evolutionary implications of social plasticity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FPSI%2F71811%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXCL%2FBIA-ANM%2F0549%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F40976%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F44848%2F2008/PT
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleProceedings of the National Academy of Sciencespt_PT
oaire.citation.volume113pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication472a9a90-c314-4462-8e3a-474f6d438206
relation.isProjectOfPublicationafaa070b-4377-4c8f-ad3c-bb09af3102e9
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