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Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation
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Abstract(s)
Group living animals use social and asocial cues to predict the presence of reward or punishment
in the environment through associative learning. The degree to which social and
asocial learning share the same mechanisms is still a matter of debate. We have used a
classical conditioning paradigm in zebrafish, in which a social (fish image) or an asocial (circle
image) conditioned stimulus (CS) have been paired with an unconditioned stimulus
(US=food), and we have used the expression of the immediate early gene c-fos to map the
neural circuits associated with each learning type. Our results show that the learning performance
is similar to social and asocial CSs. However, the brain regions activated in each
learning type are distinct and a community analysis of brain network data reveals segregated
functional submodules, which seem to be associated with different cognitive functions
involved in the learning tasks. These results suggest that, despite localized differences in
brain activity between social and asocial learning, they share a common learning module and
social learning also recruits a specific social stimulus integration module. Therefore, our
results support the occurrence of a common general-purpose learning module, that is differentially
modulated by localized activation in social and asocial learning.
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Citation
Pinho, J. S., Kareklas, K., Oliveira, R. F., Cunliffe, V., & Petri, G. (2023). Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04999-5
Publisher
Springer Nature