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Molecular epidemiology, virulence traits and antimicrobial resistance signatures of aeromonas spp. in the critically endangered iberochondrostoma lusitanicum follow geographical and seasonal patterns

2021Journal article Restricted access
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dc.contributor.authorGrilo, Miguel
dc.contributor.authorIsidoro, Sara
dc.contributor.authorChambel, Lélia
dc.contributor.authorMarques, Carolina S.
dc.contributor.authorMarques, Tiago A.
dc.contributor.authorSousa-Santos, C.
dc.contributor.authorRobalo, Joana
dc.contributor.authorOliveira, Manuela
dc.date.accessioned2021-07-19T15:46:07Z
dc.date.available2021-07-19T15:46:07Z
dc.date.issued2021
dc.description.abstractDespite the fact that freshwater fish populations are experiencing severe declines worldwide, our knowledge on the interaction between endangered populations and pathogenic agents remains scarce. In this study, we investigated the prevalence and structure of Aeromonas communities isolated from the critically endangered Iberochondrostoma lusitanicum, a model species for threatened Iberian leuciscids, as well as health parameters in this species. Additionally, we evaluated the virulence profiles, antimicrobial resistance signatures and genomic relationships of the Aeromonas isolates. Lesion prevalence, extension and body condition were deeply affected by location and seasonality, with poorer performances in the dry season. Aeromonas composition shifted among seasons and was also different across river streams. The pathogenic potential of the isolates significantly increased during the dry season. Additionally, isolates displaying clinically relevant antimicrobial resistance phenotypes (carbapenem and fluroquinolone resistance) were detected. As it inhabits intermittent rivers, often reduced to disconnected pools during the summer, the dry season is a critical period for I. lusitanicum, with lower general health status and a higher potential of infection by Aeromonas spp. Habitat quality seems a determining factor on the sustainable development of this fish species. Also, these individuals act as reservoirs of important antimicrobial resistant bacteria with potential implications for public health.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGrilo, L , Isidoro, S., Chambel, L., Marques, C. S., Marques, T. A., Sousa-Santos, C., Robalo, J. & Oliveira, M.(2021). Molecular epidemiology, virulence traits and antimicrobial resistance signatures of aeromonas spp. in the critically endangered iberochondrostoma lusitanicum follow geographical and seasonal patterns.pt_PT
dc.identifier.doi10.3390/antibiotics10070759pt_PT
dc.identifier.issn20796382
dc.identifier.urihttp://hdl.handle.net/10400.12/8246
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI Multidisciplinary Digital Publishing Institutept_PT
dc.relationMARE/UIDB/MAR/ 04292/2020pt_PT
dc.relationMARE/UIDP/MAR/04292/2020pt_PT
dc.relationCentre of Statistics and its Applications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAeroonamspt_PT
dc.subjectAntimicrobial resistancept_PT
dc.subjectVirulencept_PT
dc.subjectTypingpt_PT
dc.subjectLeuciscidpt_PT
dc.subjectFishpt_PT
dc.titleMolecular epidemiology, virulence traits and antimicrobial resistance signatures of aeromonas spp. in the critically endangered iberochondrostoma lusitanicum follow geographical and seasonal patternspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage26pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGrilo
person.familyNameMarcão Chambel
person.familyNameSegurado Marques
person.familyNameMarques
person.familyNameSousa Santos
person.familyNameRobalo
person.familyNameOliveira
person.givenNameMiguel
person.givenNameLélia Mariana
person.givenNameCarolina
person.givenNameTiago A.
person.givenNameCarla
person.givenNameJoana
person.givenNameManuela
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person.identifier.ridN-9960-2014
person.identifier.scopus-author-id57195729611
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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