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Impaired antioxidant defenses and DNA damage in the European glass eel (Anguilla anguilla) exposed to ocean warming and acidification. Science of the Total Environment, 774

2021Journal article Open access
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dc.contributor.authorLopes, Ana Rita
dc.contributor.authorFigueiredo, Cátia
dc.contributor.authorSampaio, Eduardo
dc.contributor.authorDiniz, Mário
dc.contributor.authorRosa, Rui
dc.contributor.authorGrilo, Tiago F.
dc.date.accessioned2021-04-23T11:12:15Z
dc.date.available2021-04-23T11:12:15Z
dc.date.issued2021
dc.description.abstractThe European eel (Anguilla anguilla) has attracted scientific inquiry for centuries due to its singular biological traits. Within the European Union, glass eel fisheries have declined sharply since 1980, from up to 2000 t (t) to 62.2 t in 2018, placing wild populations under higher risk of extinction. Among the major causes of glass eels collapse, climate change has become a growing worldwide issue, specifically ocean warming and acidification, but, to our knowledge, data on physiological and biochemical responses of glass eels to these stressors is limited. Within this context, we selected some representative biomarkers [e.g. glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (TAC), heat shock proteins (HSP70), ubiquitin (Ub) and DNA damage] to study physiological responses of the European glass eel under distinct laboratory-climate change scenarios, such as increased water temperature (+ 4 °C) and pH reduction (- 0.4 units), for 12 weeks. Overall, the antioxidant enzymatic machinery was impaired, both in the muscle and viscera, manifested by significant changes in CAT, GPx and TAC. Heat shock response varied differently between tissues, increasing with temperature in the muscle, but not in the viscera, and decreasing in both tissues under acidification. The inability of HSP to maintain functional protein conformation was responsible for boosting the production of Ub, particularly under warming and acidification, as sole stressors. The overproduction of reactive oxygen species (ROS), either elicited by warming - due to increased metabolic demand - or acidification - through H+ interaction with O2-, generating H2O2 - overwhelmed defense mechanisms, causing oxidative stress and consequently leading to protein and DNA damage. Our results emphasize the vulnerability of eels' early life stages to climate change, with potential cascading consequences to adult stocks.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCT, CLIMATOXEELpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLopes, A. R., Figueiredo, C., Sampaio, E., Diniz, M., Rosa, R. Grilo, T. F. (2021). Impaired antioxidant defenses and DNA damage in the European glass eel (Anguilla anguilla) exposed to ocean warming and acidification. Science of the Total Environment, 774, https://doi.org/10.1016/j.scitotenv.2021.145499pt_PT
dc.identifier.doi10.1016/j.scitotenv.2021.145499pt_PT
dc.identifier.issn00489697
dc.identifier.urihttp://hdl.handle.net/10400.12/8101
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPTDC/AAG-GLO/ 3795/2014pt_PT
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationSFRH/BD/ 131771/2017pt_PT
dc.relationEffects of Rare Earth Elements on early life stages of marine organisms under a changing ocean
dc.relationApplied Molecular Biosciences Unit
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectDNA Damagept_PT
dc.subjectHydrogen Peroxidept_PT
dc.subjectHydrogen-Ion Concentrationpt_PT
dc.subjectOceans and Seaspt_PT
dc.subjectAnguillapt_PT
dc.titleImpaired antioxidant defenses and DNA damage in the European glass eel (Anguilla anguilla) exposed to ocean warming and acidification. Science of the Total Environment, 774pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitleEffects of Rare Earth Elements on early life stages of marine organisms under a changing ocean
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAR%2F04292%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130023%2F2017/PT
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oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage145499pt_PT
oaire.citation.titleScience of The Total Environmentpt_PT
oaire.citation.volume774pt_PT
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person.familyNameLopes
person.familyNameFigueiredo
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person.familyNameDiniz
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person.familyNameFernandes Grilo
person.givenNameAna Rita
person.givenNameCátia Alexandra
person.givenNameEduardo
person.givenNameMário
person.givenNameRui
person.givenNameTiago
person.identifierH-3227-2014
person.identifierAAM-4916-2020
person.identifierhttps://scholar.google.com/citations?user=WPP-l58AAAAJ&hl=en
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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