Repository logo
 
Publication

Open-label placebo treatment in chronic low back pain: A randomized controlled trial

2016Journal article Open access
Simple item page
dc.contributor.authorCarvalho, Cláudia Maria Constante Ferreira de
dc.contributor.authorJoaquim António Machado Caetano
dc.contributor.authorCunha, Lidia
dc.contributor.authorRebouta, Paula
dc.contributor.authorKaptchuk, Ted J.
dc.contributor.authorKirsch, Irving
dc.date.accessioned2016-10-29T11:28:36Z
dc.date.available2016-10-29T11:28:36Z
dc.date.issued2016
dc.description.abstractThis randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks. Pain severity was assessed on three 0- to 10-point Numeric Rating Scales, scoring maximum pain, minimum pain, and usual pain, and a composite, primary outcome, total pain score. Our other primary outcome was back-related dysfunction, assessed on the Roland-Morris Disability Questionnaire. In an exploratory follow-up, participants on TAU received placebo pills for 3 additional weeks. We randomized 97 adults reporting persistent low back pain for more than 3 months' duration and diagnosed by a board-certified pain specialist. Eighty-three adults completed the trial. Compared to TAU, OLP elicited greater pain reduction on each of the three 0- to 10-point Numeric Rating Scales and on the 0- to 10-point composite pain scale (P < 0.001), with moderate to large effect sizes. Pain reduction on the composite Numeric Rating Scales was 1.5 (95% confidence interval: 1.0-2.0) in the OLP group and 0.2 (-0.3 to 0.8) in the TAU group. Open-label placebo treatment also reduced disability compared to TAU (P < 0.001), with a large effect size. Improvement in disability scores was 2.9 (1.7-4.0) in the OLP group and 0.0 (-1.1 to 1.2) in the TAU group. After being switched to OLP, the TAU group showed significant reductions in both pain (1.5, 0.8-2.3) and disability (3.4, 2.2-4.5). Our findings suggest that OLP pills presented in a positive context may be helpful in chronic low back pain.pt_PT
dc.description.sponsorshipFoundation for the Science of the Therapeutic Encounter (F-STE); National Center for Complementary and Integrative Health; U.S. National Institutes of Healthpt_PT
dc.identifier.citationPAIN, 0, 1-7. Doi: 10.1097/j.pain.0000000000000700pt_PT
dc.identifier.doi10.1097/j.pain.0000000000000700pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.12/5019
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott, Williams & Wilkinspt_PT
dc.relation2K24 AT004095pt_PT
dc.relationR01AT008573pt_PT
dc.relationR61AT009306pt_PT
dc.relationR01AT005280pt_PT
dc.relationPO1 AT006663pt_PT
dc.relation.publisherversionhttp://journals.lww.com/pain/pages/articleviewer.aspx?year=9000&issue=00000&article=99404&type=abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPlacebopt_PT
dc.subjectChronic low back painpt_PT
dc.subjectControlled trialpt_PT
dc.titleOpen-label placebo treatment in chronic low back pain: A randomized controlled trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.endPage7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePAINpt_PT
oaire.citation.volume0pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
P, 0, 1-7.pdf
Size:
371.3 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

PSAU - Artigos em revistas internacionais