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- Effects of an individual cognitive stimulation intervention on global cognition, memory, and executive function in older adults with mild to moderate Alzheimer’s diseasePublication . Justo-Henriques, Susana I; Pérez Sáez, Enrique; Carvalho, Janessa O.; Lemos, Raquel; Ribeiro, OscarObjective: To determine the efficacy of a 12-week individual cogni-tive stimulation (iCS) intervention on global cognition, memory,and executive function of older adults with mild to moderateAlzheimer’s disease (AD). Method: Protocolized analysis using datafrom a multicenter, single-blind, randomized, parallel two-arm RCTof iCS for older adults with probable AD. A sample of 142 peoplewith probable Alzheimer’s disease attending 13 Portuguese institu-tions providing care and support services for older adults wereselected. Intervention group (n = 72) received 24 iCS sessions, twicea week for 12 weeks. Control group (n = 70) maintained their activ-ities as usual. Outcomes included global cognitive function(Mini-Mental State Examination, and Alzheimer’s Disease AssessmentScale—Cognitive Subscale), memory (Memory Alteration Test, andFree and Cued Selective Reminding Test), and executive function-ing (Frontal Assessment Battery). All participants were assessed atbaseline (T0), after the intervention (T1), and 12 weeks follow-up(T2). Results: The results showed significant improvements in mem-ory performance at follow-up for the intervention group andgreater stability in global cognition in the intervention relative tothe control group. Conclusion: The current iCS protocol showseffectiveness in cognitive functioning in older adults with probableAD, particularly for memory upon completion of the interventionand at follow-up, adding further support to previous iCS studiesshowing similar results and to the effectiveness of the currentintervention.