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Advisor(s)
Abstract(s)
An updated systematic review and meta-analysis was conducted to (1) evaluate the effects of behavioral and
psychological interventions containing a graded physical activity component upon fatigue severity, physical
functioning, physical activity and psychological distress, and to (2) examine potential moderator effects of trial
characteristics (type of control, setting, provider, length of treatment, psychological component, flexibility in
physical activity, and minimal face to face patient–provider contact). Pertinent content of selected studies was
extracted and rated on a scale of methodological quality. Sixteen randomized controlled trials (N = 2004)
were included in the meta-analyses. Significant small to medium effect sizes (Hedge's g = 0.25 to g = 0.66)
were found for all outcomes at post-treatment (M = 5.2 months) and follow-up (M = 11.7 months), with the
exception of physical activity at post-treatment (g = 0.11). The largest effects were found for fatigue severity
(g = 0.61 to g = 0.66). Subgroup analyses revealed that minimal contact interventions had additional beneficial
effects upon fatigue (g = 0.96) and depression (g = 0.85). Interventions provided by psychologistspsychotherapists
and interventions conducted in secondary–tertiary settings also resulted in more beneficial
effects on fatigue. We found some indication of publication bias. The small number of studies and variability between
them are limitations of this study. Future research should explore additional moderating effects in order to
improve the effectiveness of interventions.
Description
Keywords
Meta-analysis Chronic fatigue Graded physical activity/exercise Moderators Psychological Interventions
Citation
Clinical Psychology Review, 40, 123-137. doi: 10.1016/j.cpr.2015.05.009
Publisher
Elsevier