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Oxytocin and social isolation: Nonapeptide regulation of social homeostasis

dc.contributor.authorKareklas, Kyriacos
dc.contributor.authorOliveira, Rui F.
dc.date.accessioned2024-11-29T15:15:36Z
dc.date.available2024-11-29T15:15:36Z
dc.date.issued2024
dc.description.abstractSocial isolation imposes physiological and behavioural effects that can have a severe impact on health, but the underlying mechanisms remain poorly understood. We reason that mechanisms responsible for the motivation to interact with others and the cognitive assessment of social interactions also mediate the effects of the lack of social interactions. This is because social isolation stress depends on the ability to maintain homeostasis against objective changes from sensory deprivation under physical isolation and subjective changes from perceived unmet social needs. Here, we review evidence for the conserved role played by the oxytocin neurosignalling system via its modulation of social decision-making and stress management. We discuss how oxytocin underlies the influence of both objective and subjective changes in social conditions, by featuring prominently in the control of motivational and cognitive functions in conserved brain regions, and eliciting ultimate health outcomes through interactions with other neuroendocrine systems. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKareklas, K., & Oliveira, R. F. (2024). Oxytocin and social isolation: Nonapeptide regulation of social homeostasis.Masterclass in Neuroendocrinology. Springer Nature, 16, 195-215. https://doi.org/10.1007/978-3-031-51112-7_8pt_PT
dc.identifier.doi10.1007/978-3-031-51112-7_8pt_PT
dc.identifier.issn26622068
dc.identifier.urihttp://hdl.handle.net/10400.12/10032
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPTDC/BIA-COM/3068/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHealthpt_PT
dc.subjectHomeostasispt_PT
dc.subjectNeuroendocrinept_PT
dc.subjectOxytocinpt_PT
dc.subjectSocial isolationpt_PT
dc.titleOxytocin and social isolation: Nonapeptide regulation of social homeostasispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage215pt_PT
oaire.citation.startPage195pt_PT
oaire.citation.titleMasterclass in Neuroendocrinologypt_PT
oaire.citation.volume16pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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