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Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish

2023Journal article Restricted access
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dc.contributor.authorAkinrinade, Ibukun
dc.contributor.authorKareklas, Kyriacos
dc.contributor.authorTeles, Magda C
dc.contributor.authorReis, Thais K.
dc.contributor.authorGliksberg, Michael
dc.contributor.authorPetri, Giovanni
dc.contributor.authorLevkowitz, Gil
dc.contributor.authorOliveira, Rui F.
dc.date.accessioned2024-04-04T15:36:27Z
dc.date.available2024-04-04T15:36:27Z
dc.date.issued2023
dc.description.abstractEmotional contagion is the most ancestral form of empathy. We tested to what extent the proximate mechanisms of emotional contagion are evolutionarily conserved by assessing the role of oxytocin, known to regulate empathic behaviors in mammals, in social fear contagion in zebrafish. Using oxytocin and oxytocin receptor mutants, we show that oxytocin is both necessary and sufficient for observer zebrafish to imitate the distressed behavior of conspecific demonstrators. The brain regions associated with emotional contagion in zebrafish are homologous to those involved in the same process in rodents (e.g., striatum, lateral septum), receiving direct projections from oxytocinergic neurons located in the pre-optic area. Together, our results support an evolutionary conserved role for oxytocin as a key regulator of basic empathic behaviors across vertebrates. Copyright © 2023 The Authors, some rights reserved.pt_PT
dc.description.sponsorshipFEDER; Fundação para a Ciência e Tecnologia - FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAkinrinade, I., Kareklas, K., Teles, M. C., Reis, T. K., Gliksberg, M., Petri, G., Levkowitz, G., & Oliveira, R. F. (2023). Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish. Science, 379(6638), 1–6. https://doi.org/10.1126/science.abq5158pt_PT
dc.identifier.doi10.1126/science.abq5158pt_PT
dc.identifier.issn10959203
dc.identifier.urihttp://hdl.handle.net/10400.12/9710
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association for the Advancement of Sciencept_PT
dc.relationBI-POCI-01-0145-Fpt_PT
dc.relation22122pt_PT
dc.relationISBOA-01-0145-FEDER-022170pt_PT
dc.subjectAnimalspt_PT
dc.subjectEmotionspt_PT
dc.subjectEmpathypt_PT
dc.subjectFearpt_PT
dc.subjectOxytocinpt_PT
dc.subjectRodentiapt_PT
dc.subjectSocial Behaviorpt_PT
dc.subjectZebrafishpt_PT
dc.titleEvolutionarily conserved role of oxytocin in social fear contagion in zebrafishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Statespt_PT
oaire.citation.endPage1237pt_PT
oaire.citation.issue6638pt_PT
oaire.citation.startPage1232pt_PT
oaire.citation.titleSciencept_PT
oaire.citation.volume379pt_PT
person.familyNameAkinrinade
person.familyNameKareklas
person.familyNameTeles
person.familyNameGliksberg
person.familyNamePetri
person.familyNameLevkowitz
person.familyNameOliveira
person.givenNameIbukun
person.givenNameKyriacos
person.givenNameMagda C
person.givenNameMichael
person.givenNameGiovanni
person.givenNameGil
person.givenNameRui
person.identifier74371
person.identifier.ciencia-idE81E-61AE-44BC
person.identifier.ciencia-id0319-D788-C2EC
person.identifier.ciencia-id5611-5DC0-F794
person.identifier.ciencia-id611C-50AD-6CE7
person.identifier.orcid0000-0002-4018-2641
person.identifier.orcid0000-0003-2453-9556
person.identifier.orcid0000-0002-3051-8332
person.identifier.orcid0000-0002-4480-0494
person.identifier.orcid0000-0003-1847-5031
person.identifier.orcid0000-0002-3896-1881
person.identifier.orcid0000-0003-1528-618X
person.identifier.ridA-3581-2013
person.identifier.scopus-author-id55923137600
person.identifier.scopus-author-id16200314100
person.identifier.scopus-author-id6602661063
person.identifier.scopus-author-id35561080400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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