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Genetic susceptibility to the environment moderates the impact of childhood experiences on psychotic, depressive, and anxiety dimensions

2025Clinical study Open access
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datacite.subject.fosCiências Médicas::Medicina Clínica
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBarrantes-Vidal, Neus
dc.contributor.authorTorrecilla, Pilar
dc.contributor.authorMas-Bermejo, Patricia
dc.contributor.authorPapiol, Sergi
dc.contributor.authorBakermans-Kranenburg, Marian J.
dc.contributor.authorKwapil, Thomas R.
dc.contributor.authorRosa, Araceli
dc.date.accessioned2025-03-27T14:49:42Z
dc.date.available2025-03-27T14:49:42Z
dc.date.issued2025
dc.description.abstractBackground and Hypothesis: Consistent with diathesisstress models, psychosis research has focused on genetic moderation of adverse environmental exposures. In contrast, the Differential Susceptibility (DS) model suggests that the same genetic variants that increase risk-inducing effects of adverse experiences also enhance beneficial effects from positive experiences. This study examined whether individuals with high genetic susceptibility to the environment showed differential psychotic-like and affective reactivity in response to positive and negative events in daily life. Study Design: Experience sampling methodology assessed context (positive and stressful) and momentary levels of paranoia, psychotic-like experiences (PLE), and positive (PA) and negative affect (NA) in 217 non-clinical adults oversampled for schizotypy. Linear mixed models examined whether Polygenic Risk Scores of Environmental Sensitivity (PRS-ES) moderated the impact of current context on subsequent experiences. Study Results: PRS-ES moderated positive, but not stressful, context on subsequent levels of momentary paranoia, NA, and PA, but not PLE. Genetic and environmental (G × E) interactions indicated diathesis-stress at lower thresholds of PRS-ES, but a DS model at the highest threshold of the PRS-ES. Participants with elevated PRS-ES showed increased paranoia and NA and decreased PA in subsequent assessments when reporting low levels of positive situations, but also decreased paranoia and NA and increased PA when rating contexts as positive. Conclusions: Findings support the influence of genetic sensitivity to the environment on psychotic-like and affective reactivity in daily life, particularly in response to positive contexts. This highlights the transdiagnostic protective role of positive experiences and informs ecological momentary interventions.eng
dc.description.sponsorshipMinisterio de Ciencia e Innovación; Generalitat de Catalunya; Centro Nacional de Genotipado; Agencia de Gestión de Ayudas Universitarias y de Investigación
dc.identifier.citationBarrantes-Vidal, N., Torrecilla, P., Papiol, S., Rosa, A., Mas-Bermejo, P., Bakermans-Kranenburg, M. J., & Kwapil, T. R. (2025). Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and affective reactivity in daily life. Schizophrenia Bulletin, 51(2), S74–S84. https://doi.org/10.1093/schbul/sbad162
dc.identifier.doi10.1093/schbul/sbad162
dc.identifier.issn05867614
dc.identifier.urihttp://hdl.handle.net/10400.12/13507
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relationPSI2017-91814-EXP
dc.relationPID2020- 119211RB-I00
dc.relation2021SGR01010
dc.relationCEGEN-PRB3- ISCIII
dc.relationPRE2018- 085299
dc.relation2021-FISDU-00032
dc.relation.hasversionhttps://academic.oup.com/schizophreniabulletin/article/51/Supplement_2/S74/8051729
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSchizotypy
dc.subjectPsychosis
dc.subjectGene–environment interaction
dc.subjectExperience sampling methodology
dc.subjectDifferential susceptibility
dc.subjectPolygenic Risk Score
dc.titleGenetic susceptibility to the environment moderates the impact of childhood experiences on psychotic, depressive, and anxiety dimensionseng
dc.typeclinical study
dspace.entity.typePublication
oaire.citation.endPageS84
oaire.citation.issueS2
oaire.citation.startPageS74
oaire.citation.titleSchizophrenia Bulletin
oaire.citation.volume51
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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