Percorrer por autor "Budniok, Samuel"
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- Interdependency between oxytocin and dopamine in trust-based learning in micePublication . Budniok, Samuel; Callaerts-Vegh, Zsuzsanna; Bakermans-Kranenburg, Marian; Bosmans, Guy; D’Hooge, RudiOxytocin (OT) is a neuropeptide implicated in complex social behaviors such as trust and attachment, yet the neural mechanisms underlying its effects remain unclear. OT is thought to modulate behavior by enhancing salience of social cues and attenuating prediction error (PE) processing, the discrepancy between expected and actual outcomes that drives learning. Since both salience coding and PE processing involve dopamine (DA), we investigated OT and DA interdependency in social safety learning using the social transmission of food preference (STFP) paradigm. In STFP, mice overcome neophobia towards novel food after a conspecific demonstrator signals its safety. We interpreted STFP acquisition as a functional parallel to human trust-based learning and found that OT enhanced demonstrated food preference in a trust acquisition condition, but only when DA signaling was intact. In a trust violation condition, the expectation of food safety was violated by pairing demonstrated food with lithium chloride (LiCl)-induced aversion. Updating was blocked after OT administration and non significantly reduced after DA depletion, resulting in a continued preference for demonstrated food. However, this effect was absent when OT was administered under DA depletion. These findings reveal a functional interaction between the OT and DA systems in social safety learning, which may have important implications for OT’s potential in treating disorders involving DA dysfunction.
- The moderating role of oxytocin in the association between parental support and change in secure attachment developmentPublication . Budniok, Samuel; Bakermans-Kranenburg, Marian; Bosmans, GuyAccording to the Learning Theory of Attachment, neuroendocrinological processes affect the association between parental support and change in attachment. The current study aimed to test this assumption for oxytocin (OT) given its role in social behavior. We conducted a three-wave longitudinal study in which 91 children (56% girls, Mage = 9.55, SDage = 0.63) participated. Change in attachment was assessed from Wave 1 to Wave 3 and was indexed by measuring trust in maternal support and Secure Base Script (SBS) knowledge. Measures of salivary child OT and parental support (child and mother report) were obtained during respectively the first and last wave. Results indicated that child-reported parental support was positively related to change in trust and more so for children with high OT levels. No (moderation) effects were found for SBS knowledge. Overall, these findings illustrate the importance of considering biological factors along with experienced parenting to explain differences in attachment.