Percorrer por autor "Bosmans, Guy"
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- Exploring the role of OXTR gene methylation in attachment development: A longitudinal studyPublication . Cuyvers, Bien; Ein‐Dor, Tsachi; Houbrechts, Melisse; Freson, Kathleen; Goossens, Luc; Van Den Noortgate, Wim; Van Leeuwen, Karla; Bijttebier, Patricia; Claes, Stephan; Turner, Jonathan; Chubar, Viktoria; Bakermans‐Kranenburg, Marian J.; Bosmans, Guyhe current study explored longitudinally whether oxytocin receptor gene methyla-tion (OXTRm) changes moderated the association between parental sensitivity changesand children’s attachment changes over three waves. Six hundred six Flemish children(10–12 years, 42.8%–44.8% boys) completed attachment measures and provided sali-vary OXTRm data on seven CpG sites. Their parents reported their sensitive parenting.Results suggest that OXTRm changes hardly link to attachment (in)security changesafter the age of 10. Some support was found for interaction effects between parentalsensitivity changes and OXTRm changes on attachment changes over time. Effects sug-gest that for children with increased OXTRm in the promotor region and decreasedmethylation in the inhibitor region over time, increased parental sensitivity was asso-ciated with increased secure attachment and decreased insecure attachment overtime.
- Interdependency between oxytocin and dopamine in trust-based learning in micePublication . Budniok, Samuel; Callaerts-Vegh, Zsuzsanna; Bakermans-Kranenburg, Marian; Bosmans, Guy; D’Hooge, RudiOxytocin (OT) is a neuropeptide implicated in complex social behaviors such as trust and attachment, yet the neural mechanisms underlying its effects remain unclear. OT is thought to modulate behavior by enhancing salience of social cues and attenuating prediction error (PE) processing, the discrepancy between expected and actual outcomes that drives learning. Since both salience coding and PE processing involve dopamine (DA), we investigated OT and DA interdependency in social safety learning using the social transmission of food preference (STFP) paradigm. In STFP, mice overcome neophobia towards novel food after a conspecific demonstrator signals its safety. We interpreted STFP acquisition as a functional parallel to human trust-based learning and found that OT enhanced demonstrated food preference in a trust acquisition condition, but only when DA signaling was intact. In a trust violation condition, the expectation of food safety was violated by pairing demonstrated food with lithium chloride (LiCl)-induced aversion. Updating was blocked after OT administration and non significantly reduced after DA depletion, resulting in a continued preference for demonstrated food. However, this effect was absent when OT was administered under DA depletion. These findings reveal a functional interaction between the OT and DA systems in social safety learning, which may have important implications for OT’s potential in treating disorders involving DA dysfunction.
- Oxytocin and state attachment responses to secure base support after stress in middle childhoodPublication . Cuyvers, Bien; Van IJzendoorn, Marinus; Bakermans-Kranenburg, Marian; Verhaeghe, Johan; Molenberghs, Geert; LAFIT, GINETTE; Houbrechts, Melisse; Bosmans, GuyWe tried to replicate the finding that receiving care increases children’s oxytocin and secure state attachment levels, and tested whether secure trait attachment moderates the oxytocin and state attachment response to care. 109 children (9-11 years old; M = 9.59; SD = 0.63; 34.9% boys) participated in a within-subject experiment. After stress induction (Trier Social Stress Test), children first remained alone and then received maternal secure base support. Salivary oxytocin was measured eight times. Secure trait and state attachment were measured with questionnaires, and Secure Base Script knowledge was assessed. Oxytocin levels increased after receiving secure base support from mother after having been alone. Secure state attachment changed less. Trait attachment and Secure Base Script knowledge did not moderate oxytocin or state attachment responses to support. This might mean that, regardless of the attachment history, in-the-moment positive attachment experiences might have a beneficial effect on trait attachment development in middle childhood.
- The moderating role of oxytocin in the association between parental support and change in secure attachment developmentPublication . Budniok, Samuel; Bakermans-Kranenburg, Marian; Bosmans, GuyAccording to the Learning Theory of Attachment, neuroendocrinological processes affect the association between parental support and change in attachment. The current study aimed to test this assumption for oxytocin (OT) given its role in social behavior. We conducted a three-wave longitudinal study in which 91 children (56% girls, Mage = 9.55, SDage = 0.63) participated. Change in attachment was assessed from Wave 1 to Wave 3 and was indexed by measuring trust in maternal support and Secure Base Script (SBS) knowledge. Measures of salivary child OT and parental support (child and mother report) were obtained during respectively the first and last wave. Results indicated that child-reported parental support was positively related to change in trust and more so for children with high OT levels. No (moderation) effects were found for SBS knowledge. Overall, these findings illustrate the importance of considering biological factors along with experienced parenting to explain differences in attachment.