Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.12/5307
Título: Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
Autor: Wircer, Einav
Blechman, Janna
Borodovsky, Nataliya
Tsoory, Michael
Nunes, Ana Rita
Oliveira, Rui Filipe
Levkowitz, Gil
Palavras-chave: Paraventricular nucleus
Receptor gene
Larval zebrafish
Cell lineages
Preoptic area
Data: 2017
Editora: eLife Sciences Publications
Citação: eLife, 6, 1-25. Doi: 10.7554/eLife.22170
Resumo: Proper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We show that developmental mutations in the zebrafish paralogous gene otpa but not otpb affect both stress response and social preference. These behavioral phenotypes were associated with developmental alterations in oxytocinergic (OXT) neurons. Thus, otpa and otpb differentially regulate neuropeptide switching in a newly identified subset of OXT neurons that co-express the corticotropin-releasing hormone (CRH). Single-cell analysis revealed that these neurons project mostly to the hindbrain and spinal cord. Ablation of this neuronal subset specifically reduced adult social preference without affecting stress behavior, thereby uncoupling the contribution of a specific OXT cluster to social behavior from the general otpa(-/-) deficits. Our findings reveal a new role for Otp in controlling developmental neuropeptide balance in a discrete OXT circuit whose disrupted development affects social behavior.
Peer review: yes
URI: http://hdl.handle.net/10400.12/5307
DOI: 10.7554/eLife.22170
ISSN: 2050-084X
Versão do Editor: https://elifesciences.org/content/6/e22170
Aparece nas colecções:BCOMP - Artigos em revistas internacionais

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