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|Título:||Open-label placebo treatment in chronic low back pain: A randomized controlled trial|
|Autor:||Carvalho, Cláudia Maria Constante Ferreira de|
Joaquim António Machado Caetano
Kaptchuk, Ted J.
Chronic low back pain
|Editora:||Lippincott, Williams & Wilkins|
|Citação:||PAIN, 0, 1-7. Doi: 10.1097/j.pain.0000000000000700|
|Resumo:||This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks. Pain severity was assessed on three 0- to 10-point Numeric Rating Scales, scoring maximum pain, minimum pain, and usual pain, and a composite, primary outcome, total pain score. Our other primary outcome was back-related dysfunction, assessed on the Roland-Morris Disability Questionnaire. In an exploratory follow-up, participants on TAU received placebo pills for 3 additional weeks. We randomized 97 adults reporting persistent low back pain for more than 3 months' duration and diagnosed by a board-certified pain specialist. Eighty-three adults completed the trial. Compared to TAU, OLP elicited greater pain reduction on each of the three 0- to 10-point Numeric Rating Scales and on the 0- to 10-point composite pain scale (P < 0.001), with moderate to large effect sizes. Pain reduction on the composite Numeric Rating Scales was 1.5 (95% confidence interval: 1.0-2.0) in the OLP group and 0.2 (-0.3 to 0.8) in the TAU group. Open-label placebo treatment also reduced disability compared to TAU (P < 0.001), with a large effect size. Improvement in disability scores was 2.9 (1.7-4.0) in the OLP group and 0.0 (-1.1 to 1.2) in the TAU group. After being switched to OLP, the TAU group showed significant reductions in both pain (1.5, 0.8-2.3) and disability (3.4, 2.2-4.5). Our findings suggest that OLP pills presented in a positive context may be helpful in chronic low back pain.|
|Versão do Editor:||http://journals.lww.com/pain/pages/articleviewer.aspx?year=9000&issue=00000&article=99404&type=abstract|
|Aparece nas colecções:||PSAU - Artigos em revistas internacionais|
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