Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.12/4518
Título: Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain
Autor: Oliveira, Rui Filipe
Simões, José Miguel
Teles, Magda
Oliveira, Catarina R.
Becker, Jorg D.
Lopes, João Sollari
Palavras-chave: Social dominance
Mutual assessment
Gene expression
Social genomics
Data: 2016
Editora: National Academy of Science
Citação: Proceedings of the National Academy of Sciences, 113, 654-661. doi:10.1073/pnas.1514292113
Resumo: Group living animals must be able to express different behavior profiles depending on their social status. Therefore, the same genotype may translate into different behavioral phenotypes through socially driven differential gene expression. However, how social information is translated into a neurogenomic response and what are the specific cues in a social interaction that signal a change in social status are questions that have remained unanswered. Here, we show for the first time, to our knowledge, that the switch between status-specific neurogenomic states relies on the assessment of fight outcome rather than just on self- or opponent-only assessment of fighting ability. For this purpose, we manipulated the perception of fight outcome in male zebrafish and measured its impact on the brain transcriptome using a zebrafish whole genome gene chip. Males fought either a real opponent, and a winner and a loser were identified, or their own image on a mirror, in which case, despite expressing aggressive behavior, males did not experience either a victory or a defeat. Massive changes in the brain transcriptome were observed in real opponent fighters, with losers displaying both a higher number of differentially expressed genes and of coexpressed gene modules than winners. In contrast, mirror fighters expressed a neurogenomic state similar to that of noninteracting fish. The genes that responded to fight outcome included immediate early genes and genes involved in neuroplasticity and epigenetic modifications. These results indicate that, even in cognitively simple organisms such as zebrafish, neurogenomic responses underlying changes in social status rely on mutual assessment of fighting ability.
Peer review: yes
URI: http://hdl.handle.net/10400.12/4518
DOI: 10.1073/pnas.1514292113
ISSN: 0027-8424
Aparece nas colecções:BCOMP - Artigos em revistas internacionais

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