Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.12/3363
Título: A time to remember: The role of circadian clocks in learning and memory
Autor: Smarr, Benjamin L.
Jennings, Kimberly J.
Driscoll, Joseph R.
Kriegsfeld, Lance J.
Palavras-chave: Daily
Recall
Hormones
Neurogenesis
Hippocampus
Data: 2014
Editora: American Psychological Association
Citação: Behavioral Neuroscience, 128, 283-303
Resumo: The circadian system has pronounced influence on learning and memory, manifesting as marked changes in memory acquisition and recall across the day. From a mechanistic perspective, the majority of studies have investigated mammalian hippocampal-dependent learning and memory, as this system is highly tractable. The hippocampus plays a major role in learning and memory, and has the potential to integrate circadian information in many ways, including information from local, independent oscillators, and through circadian modulation of neurogenesis, synaptic remodeling, intracellular cascades, and epigenetic regulation of gene expression. These local processes are combined with input from other oscillatory systems to synergistically augment hippocampal rhythmic function. This overview presents an account of the current state of knowledge on circadian interactions with learning and memory circuitry and provides a framework for those interested in further exploring these interactions.
Peer review: yes
URI: http://hdl.handle.net/10400.12/3363
DOI: 10.1037/a0035963
ISSN: 0735-7044
Aparece nas colecções:PORG - Artigos em revistas internacionais

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