Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.12/2536
Título: The outcome of elderly patients with cognitive complaints but normal neuropsychological tests
Autor: Nunes, Teresa
Fragata, Isabel
Ribeiro, Filipa
Palma, Teresa
Maroco, João
Cannas, Jorge
Secca, Mário
Menezes, Cristina
Carmo, Isabel
Cunha, Gil
Branco, Miguel Castelo
Guerreiro, Manuela
Mendonça, Alexandre de
Palavras-chave: Aging
Alzheimer’s disease
Amygdala
Dementia
Hippocampus
Magnetic resonance imaging
Mild cognitive impairment (MCI),
Pre-MCI
Volumetry
Data: 2010
Editora: IOS Press
Citação: Journal of Alzheimer's Disease, 19, 137-145
Resumo: Elderly patients may present with prominent cognitive complaints and have performances in neuropsychological tests within the normal range for the age and education, and thus do not fulfill the criteria for mild cognitive impairment (MCI). There is insufficient evidence to support the clinical decision in these cases (“pre-MCI”). Forty-three subjects, 11 controls, 15 “pre-MCI,” and 17 MCI, were followed for about three and half years with neuropsychological testing and magnetic resonance imaging including volumetric measurements of the hippocampus and amygdala. Two of the “pre-MCI” subjects suffered cognitive and functional deterioration and were diagnosed with dementia. Although the “pre-MCI” subjects as a group had no significant deterioration in neuropsychological tests, they suffered a decline in the total hippocampal volume (P = 0.04) along the follow-up time. In contrast, all control subjects remained stable and had no volumetric decreases. As expected, MCI patients underwent significant deterioration in several neuropsychological tests, often progressed to Alzheimer’s disease, and showed decreases both in total hippocampal and amygdalar volumes. Elderly people presenting with cognitive complaints may be in an initial phase of a degenerative disorder and should be followed clinically, even if they have normal neuropsychological tests.
Peer review: yes
URI: http://hdl.handle.net/10400.12/2536
ISSN: 1387-2877
Aparece nas colecções:UIPS - Artigos em revistas internacionais

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